Infektiologische und immunologische Aspekte bei Kinderwunsch
Despite advanced techniques in reproductive medicine, including preimplantation genetic diagnosis, in some cases implantation fails even after repeated transfer of a morphologically and genetically normal embryo. This frustrating complication is called recurrent implantation failure (RIF). In additi...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | German |
| Published: |
2 July 2018
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| In: |
Gynäkologische Endokrinologie
Year: 2018, Volume: 16, Issue: 4, Pages: 261-275 |
| ISSN: | 1610-2908 |
| DOI: | 10.1007/s10304-018-0196-9 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1007/s10304-018-0196-9
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| Author Notes: | Ruben-J. Kuon, Volker Daniel, Kilian Vomstein, Maja Weber, Timo Gaiser, Bettina Toth |
| Summary: | Despite advanced techniques in reproductive medicine, including preimplantation genetic diagnosis, in some cases implantation fails even after repeated transfer of a morphologically and genetically normal embryo. This frustrating complication is called recurrent implantation failure (RIF). In addition, approximately 1-3% of couples are affected by recurrent spontaneous miscarriage (RSM). A causative factor is diagnosed in only approximately half of these cases. Recently, infectiological and immunological aspects have come into focus of diagnostics in couples affected by RIF or RSM. In addition to autoimmune factors, such as the antiphospholipid syndrome, the role of peripheral and uterine natural killer cells in implantation and miscarriage is highlighted. The latest data also indicate chronic endometritis as a risk factor for both RIF and RSM. Whether there is an overlap in the pathogenesis of RIF and RSM is currently being investigated |
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| Item Description: | Gesehen am 13.11.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1610-2908 |
| DOI: | 10.1007/s10304-018-0196-9 |