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Quantitative assessment of microperfusion by indocyanine green angiography in kidney transplantation resembles chronic morphological changes in kidney specimens

Objective ICG fluorescence angiography enables a quantitative real-time perfusion assessment in kidney transplantation. The results of intraoperative microperfusion of the kidney allograft were compared to the renal chronicity score in pre-transplantation kidney biopsy specimens. The intrarenal resi...

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Main Authors: Rother, Ulrich (Author) , Amann, Kerstin (Author) , Adler, Werner (Author) , Nawroth, Nina (Author) , Karampinis, Ioannis (Author) , Keese, Michael (Author) , Manap, Serhat (Author) , Regus, Susanne (Author) , Meyer, Alexander (Author) , Porubský, Štefan (Author) , Hilgers, Karl (Author) , Krämer, Bernhard (Author) , Lang, Werner (Author) , Nowak, Kai (Author) , Gerken, Andreas (Author)
Format: Article (Journal)
Language:English
Published: 17 January 2019
In: Microcirculation
Year: 2019, Volume: 26, Issue: 3
ISSN:1549-8719
DOI:10.1111/micc.12529
Online Access:Verlag, Volltext: https://doi.org/10.1111/micc.12529
Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/micc.12529
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Author Notes:Ulrich Rother, Kerstin Amann, Werner Adler, Nina Nawroth, Ioannis Karampinis, Michael Keese, Serhat Manap, Susanne Regus, Alexander Meyer, Stefan Porubsky, Karl Hilgers, Bernhard K. Krämer, Werner Lang, Kai Nowak, Andreas L.H. Gerken
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Summary:Objective ICG fluorescence angiography enables a quantitative real-time perfusion assessment in kidney transplantation. The results of intraoperative microperfusion of the kidney allograft were compared to the renal chronicity score in pre-transplantation kidney biopsy specimens. The intrarenal resistance index was calculated by duplex sonography as a method of reference. Methods Seventy-seven patients with end-stage renal disease undergoing kidney transplantation were prospectively included in two centers. Correlation analysis of chronic changes in kidney biopsy specimens and the IN of ICG fluorescence signal were investigated. Results The results yielded a significantly negative correlation for the renal chronicity (r = −0.294, P = 0.017) as well as the intestinal fibrosis and tubular atrophy score (r = −0.328, P = 0.007). There was a significant inverse relationship between the IN and the mean RI values of the upper pole of the kidney allograft. Conclusions In summary, fluorescence angiography reflects preexisting morphological changes of the renal cortex. ICG angiography may serve as an alternative method for the assessment of microperfusion of the kidney allograft.
Item Description:Gesehen am 18.11.2019
Physical Description:Online Resource
ISSN:1549-8719
DOI:10.1111/micc.12529

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