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Disseminated mycosis by Arthrocladium fulminans jeopardizing a patient with GATA2 deficiency

GATA2 deficiency is characterized by monocytopenia, deficiency of dendritic cells, and a variable degree of lymphocytopenia affecting B cells and NK cells, leading to an enhanced risk of mycobacterial, viral, and fungal infections. Here we present a patient with a heterozygous intronic GATA2 mutatio...

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Main Authors: Egenlauf, Benjamin (Author) , Schuhmann, Maren (Author) , Giese, Thomas (Author) , Junghanss, Thomas (Author) , Stojković, Marija (Author) , Tintelnot, Kathrin (Author) , de Hoog, Sybren (Author) , Greil, Johann (Author) , Richter, Elvira (Author) , Vehresschild, Maria (Author) , Heußel, Claus Peter (Author) , Herth, Felix (Author) , Kreuter, Michael (Author)
Format: Article (Journal)
Language:English
Published: May 2019
In: Respiration
Year: 2019, Volume: 97, Issue: 5, Pages: 472-475
ISSN:1423-0356
DOI:10.1159/000493429
Online Access:Verlag, Volltext: https://doi.org/10.1159/000493429
Verlag, Volltext: https://www.karger.com/Article/FullText/493429
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Author Notes:Egenlauf B, Schuhmann M, Giese T, Junghanss T, Stojkovic M, Tintelnot K, de Hoog S, Greil J, Richter E, Vehresschild M, Heussel CP, Herth FJF, Kreuter M
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Summary:GATA2 deficiency is characterized by monocytopenia, deficiency of dendritic cells, and a variable degree of lymphocytopenia affecting B cells and NK cells, leading to an enhanced risk of mycobacterial, viral, and fungal infections. Here we present a patient with a heterozygous intronic GATA2 mutation who acquired a fatal disseminated mycosis due to the black yeast-like fungus Arthrocladium fulminans following an infection with Mycobacterium sherrisii. This case illustrates that in patients with severe uncommon infections, immunodeficiency syndromes must be ruled out.
Item Description:Gesehen am 18.11.2019
Physical Description:Online Resource
ISSN:1423-0356
DOI:10.1159/000493429

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