Active medulloblastoma enhancers reveal subgroup-specific cellular origins

Genomic studies of the paediatric brain tumour medulloblastoma have revealed four clinically distinct molecular subgroups. In this study, the authors map active gene regulatory elements in 28 primary medulloblastoma tissues to reveal differentially regulated enhancers across the different subgroups....

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Main Authors:	Lin, Charles Y. (Author) , Zapatka, Marc (Author) , Jones, Barbara Christine (Author) , Jones, David T. W. (Author) , Kool, Marcel (Author) , Buchhalter, Ivo (Author) , Johann, Pascal-David (Author) , Chavez, Lukas (Author) , Gröschel, Stefan (Author) , Eils, Roland (Author) , Lichter, Peter (Author) , Pfister, Stefan (Author) , Kawauchi, Daisuke (Author) , Korbel, Jan Oliver (Author)
Format:	Article (Journal)
Language:	English
Published:	27 January 2016
In:	Nature Year: 2016, Volume: 530, Issue: 7588, Pages: 57-62
ISSN:	1476-4687
DOI:	10.1038/nature16546
Online Access:	Verlag, Volltext: https://doi.org/10.1038/nature16546 Verlag: https://www.nature.com/articles/nature16546
Author Notes:	Charles Y. Lin, Serap Erkek, Yiai Tong, Linlin Yin, Alexander J. Federation, Marc Zapatka, Parthiv Haldipur, Daisuke Kawauchi, Thomas Risch, Hans-Jörg Warnatz, Barbara C. Worst, Bensheng Ju, Brent A. Orr, Rhamy Zeid, Donald R. Polaski, Maia Segura-Wang, Sebastian M. Waszak, David T.W. Jones, Marcel Kool, Volker Hovestadt, Ivo Buchhalter, Laura Sieber, Pascal Johann, Lukas Chavez, Stefan Gröschel, Marina Ryzhova, Andrey Korshunov, Wenbiao Chen, Victor V. Chizhikov, Kathleen J. Millen, Vyacheslav Amstislavskiy, Hans Lehrach, Marie-Laure Yaspo, Roland Eils, Peter Lichter, Jan O. Korbel, Stefan M. Pfister, James E. Bradner & Paul A. Northcott