Calcium-Binding Proteins as Determinants of Central Nervous System Neuronal Vulnerability to Disease
Neuronal subpopulations display differential vulnerabilities to disease, but the factors that determine their susceptibility are poorly understood. Toxic increases in intracellular calcium are a key factor in several neurodegenerative processes, with calcium-binding proteins providing an important f...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
30 April 2019
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| In: |
International journal of molecular sciences
Year: 2019, Volume: 20, Issue: 9 |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms20092146 |
| Online Access: | Verlag, Volltext: https://doi.org/10.3390/ijms20092146 Verlag: https://www.mdpi.com/1422-0067/20/9/2146 
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| Author Notes: | Richard Fairless, Sarah K. Williams and Ricarda Diem |
| Summary: | Neuronal subpopulations display differential vulnerabilities to disease, but the factors that determine their susceptibility are poorly understood. Toxic increases in intracellular calcium are a key factor in several neurodegenerative processes, with calcium-binding proteins providing an important first line of defense through their ability to buffer incoming calcium, allowing the neuron to quickly achieve homeostasis. Since neurons expressing different calcium-binding proteins have been reported to be differentially susceptible to degeneration, it can be hypothesized that rather than just serving as markers of different neuronal subpopulations, they might actually be a key determinant of survival. In this review, we will summarize some of the evidence that expression of the EF-hand calcium-binding proteins, calbindin, calretinin and parvalbumin, may influence the susceptibility of distinct neuronal subpopulations to disease processes. |
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| Item Description: | Gesehen am 21.11.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms20092146 |