Relaxation-compensated APT and rNOE CEST-MRI of human brain tumors at 3 T
Purpose Relaxation-compensated CEST-MRI (i.e., the inverse metrics magnetization transfer ratio and apparent exchange-dependent relaxation) has already been shown to provide valuable information for brain tumor diagnosis at ultrahigh magnetic field strengths. This study aims at translating the estab...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2 March 2019
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| In: |
Magnetic resonance in medicine
Year: 2019, Volume: 82, Issue: 2, Pages: 622-632 |
| ISSN: | 1522-2594 |
| DOI: | 10.1002/mrm.27751 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1002/mrm.27751 Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/mrm.27751 
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| Author Notes: | Steffen Goerke, Yannick Soehngen, Anagha Deshmane, Moritz Zaiss, Johannes Breitling, Philip S. Boyd, Kai Herz, Ferdinand Zimmermann, Karel D. Klika, Heinz-Peter Schlemmer, Daniel Paech, Mark E. Ladd, Peter Bachert |
| Summary: | Purpose Relaxation-compensated CEST-MRI (i.e., the inverse metrics magnetization transfer ratio and apparent exchange-dependent relaxation) has already been shown to provide valuable information for brain tumor diagnosis at ultrahigh magnetic field strengths. This study aims at translating the established acquisition protocol at 7 T to a clinically relevant magnetic field strength of 3 T. Methods Protein model solutions were analyzed at multiple magnetic field strengths to assess the spectral widths of the amide proton transfer and relayed nuclear Overhauser effect (rNOE) signals at 3 T. This prior knowledge of the spectral range of CEST signals enabled a reliable and stable Lorentzian-fitting also at 3 T where distinct peaks are no longer resolved in the Z-spectrum. In comparison to the established acquisition protocol at 7 T, also the image readout was extended to three dimensions. Results The observed spectral range of CEST signals at 3 T was approximately ±15 ppm. Final relaxation-compensated amide proton transfer and relayed nuclear Overhauser effect contrasts were in line with previous results at 7 T. Examination of a patient with glioblastoma demonstrated the applicability of this acquisition protocol in a clinical setting. Conclusion The presented acquisition protocol allows relaxation-compensated CEST-MRI at 3 T with a 3D coverage of the human brain. Translation to a clinically relevant magnetic field strength of 3 T opens the door to trials with a large number of participants, thus enabling a comprehensive assessment of the clinical relevance of relaxation compensation in CEST-MRI. |
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| Item Description: | Gesehen am 22.11.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1522-2594 |
| DOI: | 10.1002/mrm.27751 |