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Hdac1 regulates differentiation of bipotent liver progenitor cells during regeneration via Sox9b and Cdk8

Upon liver injury in which hepatocyte proliferation is compromised, liver progenitor cells (LPCs), derived from biliary epithelial cells (BECs), differentiate into hepatocytes. Little is known about the mechanisms of LPC differentiation. We used zebrafish and mouse models of liver injury to study th...

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Bibliographische Detailangaben
Hauptverfasser: Ko, Sungjin (VerfasserIn) , Yuan, Xiaodong (VerfasserIn) , Weng, Honglei (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 26 September 2018
In: Gastroenterology
Year: 2019, Jahrgang: 156, Heft: 1, Pages: 187-202.e14
ISSN:1528-0012
DOI:10.1053/j.gastro.2018.09.039
Online-Zugang:Resolving-System, Volltext: https://doi.org/10.1053/j.gastro.2018.09.039
Verlag: http://www.sciencedirect.com/science/article/pii/S0016508518350339
Volltext
Verfasserangaben:Sungjin Ko, Jacquelyn O. Russell, Jianmin Tian, Ce Gao, Makoto Kobayashi, Rilu Feng, Xiaodong Yuan, Chen Shao, Huiguo Ding, Minakshi Poddar, Sucha Singh, Joseph Locker, Hong-Lei Weng, Satdarshan P. Monga, and Donghun Shin
Beschreibung
Zusammenfassung:Upon liver injury in which hepatocyte proliferation is compromised, liver progenitor cells (LPCs), derived from biliary epithelial cells (BECs), differentiate into hepatocytes. Little is known about the mechanisms of LPC differentiation. We used zebrafish and mouse models of liver injury to study the mechanisms.
Beschreibung:Das PDF enthält zusätzlich zum Artikel einen Anhang von 14 Seiten
Gesehen am 25.11.2019
Beschreibung:Online Resource
ISSN:1528-0012
DOI:10.1053/j.gastro.2018.09.039

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