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Hdac1 regulates differentiation of bipotent liver progenitor cells during regeneration via Sox9b and Cdk8

Upon liver injury in which hepatocyte proliferation is compromised, liver progenitor cells (LPCs), derived from biliary epithelial cells (BECs), differentiate into hepatocytes. Little is known about the mechanisms of LPC differentiation. We used zebrafish and mouse models of liver injury to study th...

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Bibliographic Details
Main Authors: Ko, Sungjin (Author) , Yuan, Xiaodong (Author) , Weng, Honglei (Author)
Format: Article (Journal)
Language:English
Published: 26 September 2018
In: Gastroenterology
Year: 2019, Volume: 156, Issue: 1, Pages: 187-202.e14
ISSN:1528-0012
DOI:10.1053/j.gastro.2018.09.039
Online Access:Resolving-System, Volltext: https://doi.org/10.1053/j.gastro.2018.09.039
Verlag: http://www.sciencedirect.com/science/article/pii/S0016508518350339
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Author Notes:Sungjin Ko, Jacquelyn O. Russell, Jianmin Tian, Ce Gao, Makoto Kobayashi, Rilu Feng, Xiaodong Yuan, Chen Shao, Huiguo Ding, Minakshi Poddar, Sucha Singh, Joseph Locker, Hong-Lei Weng, Satdarshan P. Monga, and Donghun Shin
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Summary:Upon liver injury in which hepatocyte proliferation is compromised, liver progenitor cells (LPCs), derived from biliary epithelial cells (BECs), differentiate into hepatocytes. Little is known about the mechanisms of LPC differentiation. We used zebrafish and mouse models of liver injury to study the mechanisms.
Item Description:Das PDF enthält zusätzlich zum Artikel einen Anhang von 14 Seiten
Gesehen am 25.11.2019
Physical Description:Online Resource
ISSN:1528-0012
DOI:10.1053/j.gastro.2018.09.039

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