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Loxl2 is dispensable for dermal development, homeostasis and tumour stroma formation

Lysyl oxidase-like 2 (LOXL2) is a copper-dependent monoamine oxidase that contributes to the remodelling of the extracellular matrix (ECM) by cross linkage of collagen and elastin fibres and has emerged as a potential therapeutic target in cancer and fibrosis. In the skin, LOXL2 is essential for epi...

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Main Authors: Kober, Katharina Isabelle (Author) , Géraud, Cyrill (Author) , Boutros, Michael (Author)
Format: Article (Journal)
Language:English
Published: June 28, 2018
In: PLOS ONE
Year: 2018, Volume: 13, Issue: 6
ISSN:1932-6203
DOI:10.1371/journal.pone.0199679
Online Access:Resolving-System, Volltext: https://doi.org/10.1371/journal.pone.0199679
Verlag: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199679
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Author Notes:Katharina Isabelle Kober, Amparo Cano, Cyrill Géraud, Kalle Sipilä, Seyedeh Atefeh Mobasseri, Christina Philippeos, Angela Oliveira Pisco, Andrew Stannard, Alberto Martin, Fernando Salvador, Vanesa Santos, Michael Boutros, Emanuel Rognoni, Fiona M. Watt
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Summary:Lysyl oxidase-like 2 (LOXL2) is a copper-dependent monoamine oxidase that contributes to the remodelling of the extracellular matrix (ECM) by cross linkage of collagen and elastin fibres and has emerged as a potential therapeutic target in cancer and fibrosis. In the skin, LOXL2 is essential for epidermal cell polarity and differentiation. However, its role in the dermis has not been evaluated. We found that Loxl2 is dispensable for mouse dermal development, maturation and homeostasis, yet affects dermal stiffness. Neither loss of Loxl2 nor increased Loxl2 expression affected dermal architecture following treatment with the phorbol ester TPA. Furthermore, Loxl2 expression did not alter the stroma of DMBA-TPA-induced tumours. We conclude that, although Loxl2 is expressed in both dermis and epidermis, its function appears largely confined to the epidermis.
Item Description:Gesehen am 27.11.2019
Physical Description:Online Resource
ISSN:1932-6203
DOI:10.1371/journal.pone.0199679

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