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The association of high-sensitivity cardiac troponin I and T with echocardiographic stages of heart failure with preserved ejection fraction

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Background: This study evaluates the associations between high-sensitivity troponin I and T (hs-TnI/hs-TnT) and the stages of heart failure with preserved ejection fraction (HFpEF)/diastolic dysfunction. Methods: Blood samples for biomarker measurements (hs-TnI/hs-TnT/NT-proBNP) were collected withi...

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Main Authors: Hoffmann, Julia (Author) , Behnes, Michael (Author) , Ansari, Uzair (Author) , Weidner, Kathrin (Author) , Kuche, Philipp (Author) , Rusnak, Jonas (Author) , Kim, Seung‑Hyun (Author) , Natale, Michèle (Author) , Reckord, Nadine (Author) , Lang, Siegfried (Author) , Hoffmann, Ursula (Author) , Bertsch, Thomas (Author) , Fatar, Marc (Author) , Borggrefe, Martin (Author) , Akın, Ibrahim (Author)
Format: Article (Journal)
Language:English
Published: May 21, 2019
In: Annals of clinical biochemistry
Year: 2019, Volume: 56, Issue: 4, Pages: 431-441
ISSN:1758-1001
DOI:10.1177/0004563219841644
Online Access:Verlag, Volltext: https://doi.org/10.1177/0004563219841644
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Author Notes:Julia Hoffmann, Michael Behnes, Uzair Ansari, Kathrin Weidner, Philip Kuche, Jonas Rusnak, Seung-Hyun Kim, Michele Natale, Nadine Reckord, Siegfried Lang, Ursula Hoffmann, Thomas Bertsch, Marc Fatar, Martin Borggrefe, Ibrahim Akin
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Summary:Background: This study evaluates the associations between high-sensitivity troponin I and T (hs-TnI/hs-TnT) and the stages of heart failure with preserved ejection fraction (HFpEF)/diastolic dysfunction. Methods: Blood samples for biomarker measurements (hs-TnI/hs-TnT/NT-proBNP) were collected within 24 h of routine echocardiographic examination. Patients with left ventricular ejection fraction <50%, right ventricular dysfunction and moderate-to-severe valvular heart disease were excluded. Graduation of diastolic dysfunction was determined according to current guidelines. Results: A total of 70 patients were included. Hs-TnT concentrations increased significantly according to the progression of diastolic dysfunction (P = 0.024). Hs-TnT was able to discriminate patients with diastolic dysfunction grade III (AUC = 0.737; P = 0.013), while NT-proBNP revealed a greater AUC (AUC 0.798; P = 0.002). Concentrations of hs-TnI increased only numerically according to the increasing stages of diastolic dysfunction (P = 0.353). In multivariable logistic regression models, hs-TnT concentrations > 28 ng/L were associated with diastolic dysfunction grade III (OR = 4.7, P = 0.024), even after adjusting for NT-proBNP. Conclusion: Increasing concentrations of hs-TnT may reflect the stages of diastolic dysfunction being assessed by echocardiography, whereas hs-TnI does not show any association with diastolic dysfunction.
Item Description:Gesehen am 28.11.2019
Physical Description:Online Resource
ISSN:1758-1001
DOI:10.1177/0004563219841644

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