Single-cell high-throughput technologies in cerebrospinal fluid research and diagnostics
High-throughput single-cell technologies have recently emerged as essential tools in biomedical research with great potential for clinical pathology when studying liquid and solid biopsies. We provide an update on current single-cell methods in cerebrospinal fluid research and diagnostics focusing o...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
11 June 2019
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| In: |
Frontiers in immunology
Year: 2019, Volume: 10 |
| ISSN: | 1664-3224 |
| DOI: | 10.3389/fimmu.2019.01302 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.3389/fimmu.2019.01302 Verlag, kostenfrei, Volltext: https://www.frontiersin.org/articles/10.3389/fimmu.2019.01302/full 
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| Author Notes: | Tobias V. Lanz, Anne-Katrin Pröbstel, Iris Mildenberger, Michael Platten and Lucas Schirmer |
| Summary: | High-throughput single-cell technologies have recently emerged as essential tools in biomedical research with great potential for clinical pathology when studying liquid and solid biopsies. We provide an update on current single-cell methods in cerebrospinal fluid research and diagnostics focusing on high-throughput cell-type specific proteomic and genomic technologies. Proteomic methods comprising flow cytometry and mass cytometry as well as genomic approaches including immune cell repertoire and single-cell transcriptomic studies are critically reviewed and future directions discussed. |
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| Item Description: | Gesehen am 03.12.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1664-3224 |
| DOI: | 10.3389/fimmu.2019.01302 |