State diagram for wall adhesion of red blood cells in shear flow: from crawling to flipping
Red blood cells in shear flow show a variety of different shapes due to the complex interplay between hydrodynamics and membrane elasticity. Malaria-infected red blood cells become generally adhesive and less deformable. Adhesion to a substrate leads to a reduction in shape variability and to a flip...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
19 Jun 2019
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| In: |
Soft matter
Year: 2019, Volume: 15, Issue: 27, Pages: 5511-5520 |
| ISSN: | 1744-6848 |
| DOI: | 10.1039/C9SM00677J |
| Online Access: | Verlag, Volltext: https://doi.org/10.1039/C9SM00677J Verlag: https://pubs.rsc.org/en/content/articlelanding/2019/sm/c9sm00677j 
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| Author Notes: | Anil K. Dasanna, Dmitry A. Fedosov, Gerhard Gompper and Ulrich S. Schwarz |
| Summary: | Red blood cells in shear flow show a variety of different shapes due to the complex interplay between hydrodynamics and membrane elasticity. Malaria-infected red blood cells become generally adhesive and less deformable. Adhesion to a substrate leads to a reduction in shape variability and to a flipping motion of the non-spherical shapes during the mid-stage of infection. Here, we present a complete state diagram for wall adhesion of red blood cells in shear flow obtained by simulations, using a particle-based mesoscale hydrodynamics approach, multiparticle collision dynamics. We find that cell flipping at a substrate is replaced by crawling beyond a critical shear rate, which increases with both membrane stiffness and viscosity contrast between the cytosol and suspending medium. This change in cell dynamics resembles the transition between tumbling and tank-treading for red blood cells in free shear flow. In the context of malaria infections, the flipping-crawling transition would strongly increase the adhesive interactions with the vascular endothelium, but might be suppressed by the combined effect of increased elasticity and viscosity contrast. |
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| Item Description: | Gesehen am 04.12.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1744-6848 |
| DOI: | 10.1039/C9SM00677J |