The lipid-droplet-associated protein ABHD5 protects the heart through proteolysis of HDAC4

Known as a regulator of lipolysis, ABHD5 is found to also act as a serine protease that cleaves HDAC4 in response to catecholaminergic stimulation, thus resulting in the formation of a polypeptide that protects against metabolic-stress-induced heart failure.

Bibliographic Details

Main Authors:	Jebessa, Zegeye Hailu (Author) , Dewenter, Matthias (Author) , Lehmann, Lorenz (Author) , Xu, Chang (Author) , Schreiter, Friederike (Author) , Siede, Dominik (Author) , Jones, Barbara Christine (Author) , Federico, Giuseppina (Author) , Sauer, Sven (Author) , Fischer, Tamás (Author) , Müller, Oliver J. (Author) , Dieterich, Christoph (Author) , Most, Patrick (Author) , Gröne, Hermann-Josef (Author) , Katus, Hugo (Author) , Tyedmers, Jens (Author) , Backs, Johannes (Author)
Format:	Article (Journal)
Language:	English
Published:	15 November 2019
In:	Nature metabolism Year: 2019, Volume: 1, Issue: 11, Pages: 1157-1167
ISSN:	2522-5812
DOI:	10.1038/s42255-019-0138-4
Online Access:	Resolving-System, Volltext: https://doi.org/10.1038/s42255-019-0138-4 Verlag: https://www.nature.com/articles/s42255-019-0138-4
Author Notes:	Zegeye H. Jebessa, Kumar D. Shanmukha, Matthias Dewenter, Lorenz H. Lehmann, Chang Xu, Friederike Schreiter, Dominik Siede, Xue-Min Gong, Barbara C. Worst, Giuseppina Federico, Sven W. Sauer, Tamas Fischer, Lisa Wechselberger, Oliver J. Müller, Samuel Sossalla, Christoph Dieterich, Patrick Most, Herrmann-Josef Gröne, Cedric Moro, Monika Oberer, Guenter Haemmerle, Hugo A. Katus, Jens Tyedmers and Johannes Backs