Gonadal function after busulfan compared with treosulfan in children and adolescents undergoing allogeneic hematopoietic stem cell transplant
Gonadal impairment is an important late effect with a significant impact on quality of life of transplanted patients. The aim of this study was to compare gonadal function after busulfan (Bu) or treosulfan (Treo) conditioning regimens in pre- and postpubertal children. This retrospective, multicente...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
11 May 2019
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| In: |
Biology of blood and marrow transplantation
Year: 2019, Volume: 25, Issue: 9, Pages: 1786-1791 |
| ISSN: | 1523-6536 |
| DOI: | 10.1016/j.bbmt.2019.05.005 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1016/j.bbmt.2019.05.005 Verlag: http://www.sciencedirect.com/science/article/pii/S1083879119302897 
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| Author Notes: | Maura Faraci, Tamara Diesch, Myriam Labopin, Arnaud Dalissier, Arian Lankester, Andrew Gennery, Mikael Sundin, Duygu Uckan-Cetinkaya, Marc Bierings, Anke M. J. Peters, Martina Garwer, Ansgar Schulz, Gerard Michel, Giovanna Giorgiani, Bernd Gruhn, Franco Locatelli, Stefano Giardino, Anne Uyttebroeck, Fanny Rialland, Maija Itäla-Remes, Peter Dreger, Peter J. Shaw, Victoria Bordon, Paul G. Schlegel, Karin Mellgren, Jose M. Moraleda, Katharine Patrick, Pascale Schneider, Charlotte Jubert, Anita Lawitschka, Nina Salooja, Grzegorz W. Basak, Selim Corbacioglu, Rafael Duarte, Peter Bader, on behalfof the Pediatric and Transplant Complications Working Parties of the European Society for Blood and Marrow Transplantation |
| Summary: | Gonadal impairment is an important late effect with a significant impact on quality of life of transplanted patients. The aim of this study was to compare gonadal function after busulfan (Bu) or treosulfan (Treo) conditioning regimens in pre- and postpubertal children. This retrospective, multicenter study included children transplanted in pediatric European Society for Blood and Marrow Transplantation (EBMT) centers between 1992 and 2012 who did not receive gonadotoxic chemoradiotherapy before the transplant. We evaluated 137 patients transplanted in 25 pediatric EBMT centers. Median age at transplant was 11.04 years (range, 5 to 18); 89 patients were boys and 48 girls. Eighty-nine patients were prepubertal at transplant and 48 postpubertal. One hundred eighteen children received Bu and 19 Treo. A higher proportion of girls treated with Treo in the prepubertal stage reached spontaneous puberty compared with those treated with Bu (P=.02). Spontaneous menarche was more frequent after Treo than after Bu (P < .001). Postpubertal boys and girls treated with Treo had significantly lower luteinizing hormone levels (P=.03 and P=.04, respectively) compared with the Bu group. Frequency of gonadal damage associated with Treo was significantly lower than that observed after Bu. These results need to be confirmed in a larger population. |
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| Item Description: | Gesehen am 10.12.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1523-6536 |
| DOI: | 10.1016/j.bbmt.2019.05.005 |