Ultra-Specific Isolation of Circulating Tumor Cells Enables Rare-Cell RNA Profiling
The clinical potential of circulating tumor cells (CTCs) in managing cancer metastasis is significant. However, low CTC isolation purities from patient blood have hindered sensitive molecular assays of these rare cells. Described herein is the ultra-pure isolation of CTCs from patient blood samples...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
18 April 2016
|
| In: |
Advanced science
Year: 2016, Volume: 3, Issue: 9 |
| ISSN: | 2198-3844 |
| DOI: | 10.1002/advs.201600063 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1002/advs.201600063 Verlag: https://onlinelibrary.wiley.com/doi/abs/10.1002/advs.201600063 
|
| Author Notes: | Rhonda M. Jack, Meggie M.G. Grafton, Danika Rodrigues, Maria D. Giraldez, Catherine Griffith, Robert Cieslak, Mina Zeinali, Chandan Kumar Sinha, Ebrahim Azizi, Max Wicha, Muneesh Tewari, Diane M. Simeone, and Sunitha Nagrath |
| Summary: | The clinical potential of circulating tumor cells (CTCs) in managing cancer metastasis is significant. However, low CTC isolation purities from patient blood have hindered sensitive molecular assays of these rare cells. Described herein is the ultra-pure isolation of CTCs from patient blood samples and how this platform has enabled highly specific molecular (mRNA and miRNA) profiling of patient CTCs. |
|---|---|
| Item Description: | Gesehen am 11.12.2019 |
| Physical Description: | Online Resource |
| ISSN: | 2198-3844 |
| DOI: | 10.1002/advs.201600063 |