Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy

Increased copy number alterations, indicative of chromosomal instability, is associated with poor cancer outcome. Here, metastatic colorectal cancer patients displaying intermediate-high CIN associate with improved outcome following chemotherapy and bevacizumab treatment, suggesting CIN as a predict...

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Main Authors:	Smeets, Dominiek (Author) , Miller, Ian S. (Author) , O’Connor, Darran P. (Author) , Das, Sudipto (Author) , Moran, Bruce (Author) , Boeckx, Bram (Author) , Gaiser, Timo (Author) , Betge, Johannes (Author) , Barat, Ana (Author) , Klinger, Rut (Author) , Grieken, Nicole C. T. van (Author) , Cremolini, Chiara (Author) , Prenen, Hans (Author) , Mazzone, Massimiliano (Author) , Depreeuw, Jeroen (Author) , Bacon, Orna (Author) , Fender, Bozena (Author) , Brady, Joseph (Author) , Hennessy, Bryan T. (Author) , McNamara, Deborah A. (Author) , Kay, Elaine (Author) , Verheul, Henk M. (Author) , Maarten, Neerincx (Author) , Gallagher, William M. (Author) , Murphy, Verena (Author) , Prehn, Jochen H. M. (Author) , Koopman, Miriam (Author) , Punt, Cornelis J. A. (Author) , Loupakis, Fotios (Author) , Ebert, Matthias P. A. (Author) , Ylstra, Bauke (Author) , Lambrechts, Diether (Author) , Byrne, Annette T. (Author)
Format:	Article (Journal)
Language:	English
Published:	05 October 2018
In:	Nature Communications Year: 2018, Volume: 9, Pages: 1-16
ISSN:	2041-1723
DOI:	10.1038/s41467-018-06567-6
Online Access:	Verlag, Volltext: http://dx.doi.org/10.1038/s41467-018-06567-6 Verlag, Volltext: https://www.nature.com/articles/s41467-018-06567-6
Author Notes:	Dominiek Smeets et al.