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Anti-angiogenic effects of the DPP-4 inhibitor linagliptin via inhibition of VEGFR signalling in the mouse model of oxygen-induced retinopathy

Linagliptin has protective effects on the retinal neurovascular unit but, in proliferative retinopathy, dipeptidyl peptidase 4 (DPP-4) inhibition could be detrimental. The aim of this study was to assess the effect of linagliptin on ischaemiainduced neovascularisation of the retina.

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Bibliographic Details
Main Authors: Kolibabka, Matthias (Author) , Dietrich, Nadine (Author) , Hammes, Hans-Peter (Author)
Format: Article (Journal)
Language:English
Published: 10 August 2018
In: Diabetologia
Year: 2018, Volume: 61, Issue: 11, Pages: 2412-2421
ISSN:1432-0428
DOI:10.1007/s00125-018-4701-4
Online Access:Resolving-System, Volltext: https://doi.org/10.1007/s00125-018-4701-4
Verlag: https://link.springer.com/article/10.1007%2Fs00125-018-4701-4
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Author Notes:Matthias Kolibabka, Nadine Dietrich, Thomas Klein, Hans-Peter Hammes
Description
Summary:Linagliptin has protective effects on the retinal neurovascular unit but, in proliferative retinopathy, dipeptidyl peptidase 4 (DPP-4) inhibition could be detrimental. The aim of this study was to assess the effect of linagliptin on ischaemiainduced neovascularisation of the retina.
Item Description:Gesehen am 13.12.2019
Physical Description:Online Resource
ISSN:1432-0428
DOI:10.1007/s00125-018-4701-4

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