Anti-angiogenic effects of the DPP-4 inhibitor linagliptin via inhibition of VEGFR signalling in the mouse model of oxygen-induced retinopathy
Linagliptin has protective effects on the retinal neurovascular unit but, in proliferative retinopathy, dipeptidyl peptidase 4 (DPP-4) inhibition could be detrimental. The aim of this study was to assess the effect of linagliptin on ischaemiainduced neovascularisation of the retina.
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
10 August 2018
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| In: |
Diabetologia
Year: 2018, Jahrgang: 61, Heft: 11, Pages: 2412-2421 |
| ISSN: | 1432-0428 |
| DOI: | 10.1007/s00125-018-4701-4 |
| Online-Zugang: | Resolving-System, Volltext: https://doi.org/10.1007/s00125-018-4701-4 Verlag: https://link.springer.com/article/10.1007%2Fs00125-018-4701-4 
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| Verfasserangaben: | Matthias Kolibabka, Nadine Dietrich, Thomas Klein, Hans-Peter Hammes |
| Zusammenfassung: | Linagliptin has protective effects on the retinal neurovascular unit but, in proliferative retinopathy, dipeptidyl peptidase 4 (DPP-4) inhibition could be detrimental. The aim of this study was to assess the effect of linagliptin on ischaemiainduced neovascularisation of the retina. |
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| Beschreibung: | Gesehen am 13.12.2019 |
| Beschreibung: | Online Resource |
| ISSN: | 1432-0428 |
| DOI: | 10.1007/s00125-018-4701-4 |