Investigation of the spatial structure and interactions of the genome at sub-kilobase-pair resolution using T2C
This protocol describes targeted chromatin capture (T2C), a high-resolution method to interrogate 3D chromatin organization and genomic interactions at sub-kilobase-pair resolution that requires minimal cell numbers and sequencing depth.
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
08 February 2018
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| In: |
Nature protocols
Year: 2018, Volume: 13, Issue: 3, Pages: 459-477 |
| ISSN: | 1750-2799 |
| DOI: | 10.1038/nprot.2017.132 |
| Online Access: | Resolving-System, Volltext: https://doi.org/10.1038/nprot.2017.132 Verlag: https://www.nature.com/articles/nprot.2017.132 
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| Author Notes: | Petros Kolovos, Rutger W.W. Brouwer, Christel E.M. Kockx, Michael Lesnussa, Nick Kepper, Jessica Zuin, A.M. Ali Imam, Harmen J.G. van de Werken, Kerstin S. Wendt, Tobias A. Knoch, Wilfred F.J. van IJcken, Frank Grosveld |
| Summary: | This protocol describes targeted chromatin capture (T2C), a high-resolution method to interrogate 3D chromatin organization and genomic interactions at sub-kilobase-pair resolution that requires minimal cell numbers and sequencing depth. |
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| Item Description: | Gesehen am 16.12.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1750-2799 |
| DOI: | 10.1038/nprot.2017.132 |