Investigation of the spatial structure and interactions of the genome at sub-kilobase-pair resolution using T2C

This protocol describes targeted chromatin capture (T2C), a high-resolution method to interrogate 3D chromatin organization and genomic interactions at sub-kilobase-pair resolution that requires minimal cell numbers and sequencing depth.

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Bibliographic Details
Main Authors: Kolovos, Petros (Author) , Kepper, Frank Nikolaus (Author)
Format: Article (Journal)
Language:English
Published: 08 February 2018
In: Nature protocols
Year: 2018, Volume: 13, Issue: 3, Pages: 459-477
ISSN:1750-2799
DOI:10.1038/nprot.2017.132
Online Access:Resolving-System, Volltext: https://doi.org/10.1038/nprot.2017.132
Verlag: https://www.nature.com/articles/nprot.2017.132
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Author Notes:Petros Kolovos, Rutger W.W. Brouwer, Christel E.M. Kockx, Michael Lesnussa, Nick Kepper, Jessica Zuin, A.M. Ali Imam, Harmen J.G. van de Werken, Kerstin S. Wendt, Tobias A. Knoch, Wilfred F.J. van IJcken, Frank Grosveld

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