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Simple and robust polymer-based sensor for rapid cancer detection using serum

We report a polymer-based sensor that rapidly detects cancer based on changes in serum protein levels. Using three ratiometric fluorescence outputs, this simple system identifies early stage and metastatic lung cancer with a high level of accuracy exceeding many biomarker-based assays, making it an...

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Main Authors: Le, Ngoc D. B. (Author) , Singla, Arvind K. (Author) , Geng, Yingying (Author) , Han, Jinsong (Author) , Seehafer, Kai (Author) , Prakash, Gyan (Author) , Moyano, Daniel F. (Author) , Downey, Charlene M. (Author) , Monument, Michael J. (Author) , Itani, Doha (Author) , Bunz, Uwe H. F. (Author) , Jirik, Frank R. (Author) , Rotello, Vincent M. (Author)
Format: Article (Journal)
Language:English
Published: 2019
In: Chemical communications
Year: 2019, Volume: 55, Issue: 76, Pages: 11458-11461
ISSN:1364-548X
DOI:10.1039/c9cc04854e
Online Access:Verlag, Volltext: https://doi.org/10.1039/c9cc04854e
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Author Notes:Ngoc D.B. Le, Arvind K. Singla, Yingying Geng, Jinsong Han, Kai Seehafer, Gyan Prakash, Daniel F. Moyano, Charlene M. Downey, Michael J. Monument, Doha Itani, Uwe H.F. Bunz, Frank R. Jirik and Vincent M. Rotello
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Summary:We report a polymer-based sensor that rapidly detects cancer based on changes in serum protein levels. Using three ratiometric fluorescence outputs, this simple system identifies early stage and metastatic lung cancer with a high level of accuracy exceeding many biomarker-based assays, making it an attractive strategy for point-of-care testing.
Item Description:Gesehen am 03.01.2020
Physical Description:Online Resource
ISSN:1364-548X
DOI:10.1039/c9cc04854e

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