PRC2 targeting is a therapeutic strategy for EZ score defined high-risk multiple myeloma patients and overcome resistance to IMiDs
Multiple myeloma (MM) is a malignant plasma cell disease with a poor survival, characterized by the accumulation of myeloma cells (MMCs) within the bone marrow. Epigenetic modifications in MM are associated not only with cancer development and progression, but also with drug resistance.
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| Hauptverfasser: | , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
03 October 2018
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| In: |
Clinical epigenetics
Year: 2018, Jahrgang: 10, Pages: 1-18 |
| ISSN: | 1868-7083 |
| DOI: | 10.1186/s13148-018-0554-4 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13148-018-0554-4 |
| Verfasserangaben: | Laurie Herviou, Alboukadel Kassambara, Stéphanie Boireau, Nicolas Robert, Guilhem Requirand, Carsten Müller-Tidow, Laure Vincent, Anja Seckinger, Hartmut Goldschmidt, Guillaume Cartron, Dirk Hose, Giacomo Cavalli, Jerome Moreaux |
| Zusammenfassung: | Multiple myeloma (MM) is a malignant plasma cell disease with a poor survival, characterized by the accumulation of myeloma cells (MMCs) within the bone marrow. Epigenetic modifications in MM are associated not only with cancer development and progression, but also with drug resistance. |
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| Beschreibung: | Gesehen am 26.11.2024 |
| Beschreibung: | Online Resource |
| ISSN: | 1868-7083 |
| DOI: | 10.1186/s13148-018-0554-4 |