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Multimodality cardiac computed tomography angiography and magnetic resonance with clinical-grade scanners provide robust assessment of cardiac morphology and function in rabbits

Background: Non-invasive computer tomography (CT)- and magnetic resonance (MR)-based cardiac imaging still remains challenging in rodents. To investigate the robustness of non-invasive multimodality cardiac imaging in rabbits using clinical-grade CT and MR scanners. - Methods: A total of 16 rabbi...

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Main Authors: Gitsioudis, Gitsios (Author) , Nunninger, Maximilian Martin (Author) , Missiou, Anna (Author) , Wolf, Peter Georg (Author) , Katus, Hugo (Author) , Korosoglou, Grigorios (Author)
Format: Article (Journal)
Language:English
Published: 26 August 2019
In: Journal of thoracic disease
Year: 2019, Volume: 11, Issue: 11, Pages: 4762-4771
ISSN:2077-6624
DOI:10.21037/jtd.2019.10.46
Online Access:Verlag, Volltext: https://doi.org/10.21037/jtd.2019.10.46
Verlag, Volltext: http://jtd.amegroups.com/article/view/33504
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Author Notes:Gitsios Gitsioudis, Maximilian Nunninger, Anna Missiou, Peter Wolf, Hugo A. Katus, Grigorios Korosoglou
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Summary:Background: Non-invasive computer tomography (CT)- and magnetic resonance (MR)-based cardiac imaging still remains challenging in rodents. To investigate the robustness of non-invasive multimodality cardiac imaging in rabbits using clinical-grade CT and MR scanners. - Methods: A total of 16 rabbits (2.7-4.0 kg) serially underwent cardiac-gated imaging using a clinical-grade 256-row CT and a 1.5 Tesla MR-scanner at baseline and at 4-month follow-up (16±1 weeks). Image analysis included image quality (5-grade scale), left ventricular (LV) volumes, LV stroke volume, LV diameters, LV wall thickness and ejection fraction (LVEF). - Results: Cardiac MR (CMR) and CT angiography (CTA) provide images with an overall good image quality (excellent or good quality: CMR 82% vs. CTA 78%, P=0.68). Linear regression analysis demonstrated a good correlation of all diameters (diam.) and volumes (vol.) as assessed by CTA and CMR (diam.: r=0.9, 95% CI: 0.8-0.9; vol.: r=0.8, 95% CI: 0.6-0.9; P Conclusions: Multimodality non-invasive assessment of cardiac function and aortic hemodynamics is feasible and robust in rabbits using clinical-grade and MR and CT scanners. These imaging modalities could improve serial cardiac assessment for disease monitoring in preclinical settings.
Item Description:Gesehen am 14.01.2020
Physical Description:Online Resource
ISSN:2077-6624
DOI:10.21037/jtd.2019.10.46

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