Renaissance of vancomycin: approaches for breaking antibiotic resistance in multidrug-resistant bacteria
The emergence of multidrug-resistant bacteria demands innovations in the development of new antibiotics. For decades, the glycopeptide antibiotic vancomycin has been considered as the “last resort” treatment of severe infections caused by Gram-positive bacteria. Since the discovery of the first vanc...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2020
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| In: |
Canadian journal of microbiology
Year: 2019, Volume: 66, Issue: 1, Pages: 11-16 |
| ISSN: | 1480-3275 |
| DOI: | 10.1139/cjm-2019-0309 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1139/cjm-2019-0309 Verlag: https://www.nrcresearchpress.com/doi/10.1139/cjm-2019-0309 
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| Author Notes: | Eric Mühlberg, Florian Umstätter, Christian Kleist, Cornelius Domhan, Walter Mier, and Philipp Uhl |
| Summary: | The emergence of multidrug-resistant bacteria demands innovations in the development of new antibiotics. For decades, the glycopeptide antibiotic vancomycin has been considered as the “last resort” treatment of severe infections caused by Gram-positive bacteria. Since the discovery of the first vancomycin-resistant enterococci strains in the late 1980s, the number of resistances has been steadily rising, with often life-threatening consequences. As an alternative to the generation of completely new substances, novel approaches focus on structural modifications of established antibiotics such as vancomycin to overcome these resistances. Here, we provide an overview of several promising modifications of vancomycin to restore its efficacy against vancomycin-resistant enterococci. |
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| Item Description: | Published on the web 23 September 2019 Gesehen am 17.01.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1480-3275 |
| DOI: | 10.1139/cjm-2019-0309 |