PI4KIII inhibitor enviroxime impedes the replication of the hepatitis C virus by inhibiting PI3 kinases
Abstract. Objectives: Many positive-stranded RNA viruses, including HCV, drastically remodel intracellular membranes to generate specialized environments for RNA including HCV, drastically remodel intracellular membranes to generate specialized environments for RNA replication. Phosphatidylinositol...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
14 September 2018
|
| In: |
The journal of antimicrobial chemotherapy
Year: 2018, Jahrgang: 73, Heft: 12, Pages: 3375-3384 |
| ISSN: | 1460-2091 |
| DOI: | 10.1093/jac/dky327 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1093/jac/dky327 Verlag, kostenfrei, Volltext: https://academic.oup.com/jac/article/73/12/3375/5096849 
|
| Verfasserangaben: | Leen Delang, Christian Harak, Mohammed Benkheil, Hayat Khan, Pieter Leyssen, Martin Andrews, Volker Lohmann, Johan Neyts |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1687908958 | ||
| 003 | DE-627 | ||
| 005 | 20230427215345.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200120s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/jac/dky327 |2 doi | |
| 035 | |a (DE-627)1687908958 | ||
| 035 | |a (DE-599)KXP1687908958 | ||
| 035 | |a (OCoLC)1341298287 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Delang, Leen |e VerfasserIn |0 (DE-588)1203114249 |0 (DE-627)168791253X |4 aut | |
| 245 | 1 | 0 | |a PI4KIII inhibitor enviroxime impedes the replication of the hepatitis C virus by inhibiting PI3 kinases |c Leen Delang, Christian Harak, Mohammed Benkheil, Hayat Khan, Pieter Leyssen, Martin Andrews, Volker Lohmann, Johan Neyts |
| 264 | 1 | |c 14 September 2018 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 20.01.2020 | ||
| 520 | |a Abstract. Objectives: Many positive-stranded RNA viruses, including HCV, drastically remodel intracellular membranes to generate specialized environments for RNA including HCV, drastically remodel intracellular membranes to generate specialized environments for RNA replication. Phosphatidylinositol 4-kinase III (PI4KIII)α plays an essential role in the formation of HCV replication complexes and has therefore been explored as a potential drug target. Here, we characterized the anti-HCV activity of the PI4KIII inhibitors enviroxime and BF738735 and elucidated their mechanism of action | ||
| 700 | 1 | |a Harak, Christian |d 1986- |e VerfasserIn |0 (DE-588)1060228467 |0 (DE-627)799316415 |0 (DE-576)416316840 |4 aut | |
| 700 | 1 | |a Benkheil, Mohammed |e VerfasserIn |4 aut | |
| 700 | 1 | |a Khan, Hayat |e VerfasserIn |4 aut | |
| 700 | 1 | |a Leyssen, Pieter |e VerfasserIn |4 aut | |
| 700 | 1 | |a Andrews, Martin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lohmann, Volker |e VerfasserIn |0 (DE-588)1060228807 |0 (DE-627)799317136 |0 (DE-576)416317537 |4 aut | |
| 700 | 1 | |a Neyts, Johan |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The journal of antimicrobial chemotherapy |d Oxford : Oxford Univ. Press, 1975 |g 73(2018), 12, Seite 3375-3384 |h Online-Ressource |w (DE-627)266876838 |w (DE-600)1467478-6 |w (DE-576)075144972 |x 1460-2091 |7 nnas |a PI4KIII inhibitor enviroxime impedes the replication of the hepatitis C virus by inhibiting PI3 kinases |
| 773 | 1 | 8 | |g volume:73 |g year:2018 |g number:12 |g pages:3375-3384 |g extent:10 |a PI4KIII inhibitor enviroxime impedes the replication of the hepatitis C virus by inhibiting PI3 kinases |
| 856 | 4 | 0 | |u https://doi.org/10.1093/jac/dky327 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://academic.oup.com/jac/article/73/12/3375/5096849 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200120 | ||
| 993 | |a Article | ||
| 994 | |a 2018 | ||
| 998 | |g 1060228807 |a Lohmann, Volker |m 1060228807:Lohmann, Volker |d 910000 |d 911700 |e 910000PL1060228807 |e 911700PL1060228807 |k 0/910000/ |k 1/910000/911700/ |p 7 | ||
| 998 | |g 1060228467 |a Harak, Christian |m 1060228467:Harak, Christian |d 910000 |d 911700 |e 910000PH1060228467 |e 911700PH1060228467 |k 0/910000/ |k 1/910000/911700/ |p 2 | ||
| 999 | |a KXP-PPN1687908958 |e 357691904X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"title":[{"title":"The journal of antimicrobial chemotherapy","subtitle":"JAC","title_sort":"journal of antimicrobial chemotherapy"}],"id":{"zdb":["1467478-6"],"eki":["266876838"],"issn":["1460-2091"]},"disp":"PI4KIII inhibitor enviroxime impedes the replication of the hepatitis C virus by inhibiting PI3 kinasesThe journal of antimicrobial chemotherapy","origin":[{"publisherPlace":"Oxford","dateIssuedKey":"1975","dateIssuedDisp":"1975-","publisher":"Oxford Univ. Press"}],"note":["Gesehen am 27.10.21"],"titleAlt":[{"title":"JAC"}],"pubHistory":["1.1975 -"],"part":{"extent":"10","issue":"12","pages":"3375-3384","year":"2018","volume":"73","text":"73(2018), 12, Seite 3375-3384"},"physDesc":[{"extent":"Online-Ressource"}],"recId":"266876838","type":{"bibl":"periodical","media":"Online-Ressource"},"name":{"displayForm":["the British Society for Antimicrobial Chemotherapy"]},"language":["eng"]}],"title":[{"title_sort":"PI4KIII inhibitor enviroxime impedes the replication of the hepatitis C virus by inhibiting PI3 kinases","title":"PI4KIII inhibitor enviroxime impedes the replication of the hepatitis C virus by inhibiting PI3 kinases"}],"physDesc":[{"extent":"10 S."}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"eki":["1687908958"],"doi":["10.1093/jac/dky327"]},"recId":"1687908958","origin":[{"dateIssuedDisp":"14 September 2018","dateIssuedKey":"2018"}],"name":{"displayForm":["Leen Delang, Christian Harak, Mohammed Benkheil, Hayat Khan, Pieter Leyssen, Martin Andrews, Volker Lohmann, Johan Neyts"]},"language":["eng"],"note":["Gesehen am 20.01.2020"],"person":[{"given":"Leen","display":"Delang, Leen","family":"Delang","role":"aut"},{"given":"Christian","display":"Harak, Christian","family":"Harak","role":"aut"},{"role":"aut","family":"Benkheil","display":"Benkheil, Mohammed","given":"Mohammed"},{"given":"Hayat","family":"Khan","role":"aut","display":"Khan, Hayat"},{"role":"aut","family":"Leyssen","display":"Leyssen, Pieter","given":"Pieter"},{"given":"Martin","role":"aut","family":"Andrews","display":"Andrews, Martin"},{"display":"Lohmann, Volker","family":"Lohmann","role":"aut","given":"Volker"},{"family":"Neyts","role":"aut","display":"Neyts, Johan","given":"Johan"}]} | ||
| SRT | |a DELANGLEENPI4KIIIINH1420 | ||