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ER-shaping atlastin proteins act as central hubs to promote flavivirus replication and virion assembly

Flavivirus infection leads to a rearrangement of host cell ER membranes that creates an environment permissive to viral replication. The morphology of these membrane rearrangements is known, but the mechanisms involved are unclear. Here, atlastins—ER-resident membrane-bound GTPases of the dynamin fa...

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Main Authors: Neufeldt, Christopher (Author) , Cortese, Mirko (Author) , Scaturro, Pietro (Author) , Cerikan, Berati (Author) , Wideman, Jeremy G. (Author) , Tabata, Keisuke (Author) , Moraes, Thaís (Author) , Aliaksiuk, Volha (Author) , Pichlmair, Andreas (Author) , Bartenschlager, Ralf (Author)
Format: Article (Journal)
Language:English
Published: 21 October 2019
In: Nature microbiology
Year: 2019, Volume: 4, Issue: 12, Pages: 2416-2429
ISSN:2058-5276
DOI:10.1038/s41564-019-0586-3
Online Access:Verlag, Volltext: https://doi.org/10.1038/s41564-019-0586-3
Verlag, Volltext: https://www.nature.com/articles/s41564-019-0586-3
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Author Notes:Christopher J. Neufeldt, Mirko Cortese, Pietro Scaturro, Berati Cerikan, Jeremy G. Wideman, Keisuke Tabata, Thaís Moraes, Olga Oleksiuk, Andreas Pichlmair & Ralf Bartenschlager
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Summary:Flavivirus infection leads to a rearrangement of host cell ER membranes that creates an environment permissive to viral replication. The morphology of these membrane rearrangements is known, but the mechanisms involved are unclear. Here, atlastins—ER-resident membrane-bound GTPases of the dynamin family—are shown to be targeted by flaviviruses to establish their replication organelle and for virion maturation and secretion.
Item Description:Gesehen am 21.01.2020
Physical Description:Online Resource
ISSN:2058-5276
DOI:10.1038/s41564-019-0586-3

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