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Impairment of the Akt pathway in transplanted Type 1 diabetic hearts is associated with post-transplant graft injury

The use of ‘marginal’ hearts, such as from donors with diabetes mellitus (DM), could offer an opportunity to expand the donor pool in cardiac transplantation. Previous studies have shown that the phosphatidylinositol-3-kinase (PI3K)/Akt pathway is altered after ischaemia/reperfusion injury in the di...

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Main Authors: Korkmaz-İçöz, Sevil (Author) , Li, Shiliang (Author) , Loganathan, Sivakkanan (Author) , Ruppert, Mihály (Author) , Brlecic, Paige (Author) , Veres, Gábor (Author) , Fleming, Thomas (Author) , Brune, Maik (Author) , Most, Patrick (Author) , Karck, Matthias (Author) , Szabó, Gábor (Author)
Format: Article (Journal)
Language:English
Published: 14 June 2018
In: Interactive cardiovascular and thoracic surgery
Year: 2018, Volume: 27, Issue: 6, Pages: 884-894
ISSN:1569-9285
DOI:10.1093/icvts/ivy188
Online Access:Resolving-System, Volltext: https://doi.org/10.1093/icvts/ivy188
Verlag: https://academic.oup.com/icvts/article/27/6/884/5038106
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Author Notes:Sevil Korkmaz-Icöz, Shiliang Li, Sivakkanan Loganathan, Tamás Radovits, Mihály Ruppert, Paige Brlecic, Alex Ali Sayour, Gábor Veres, Thomas Fleming, Maik Brune, Patrick Most, Matthias Karck and Gábor Szabó
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Summary:The use of ‘marginal’ hearts, such as from donors with diabetes mellitus (DM), could offer an opportunity to expand the donor pool in cardiac transplantation. Previous studies have shown that the phosphatidylinositol-3-kinase (PI3K)/Akt pathway is altered after ischaemia/reperfusion injury in the diabetic myocardium. We hypothesized that DM-induced cardiac dysfunction in donors is further impaired after heart transplantation and that PI3K/Akt-pathway alterations may be one of the underlying pathomechanisms.
Item Description:Gesehen am 22.01.2020
Physical Description:Online Resource
ISSN:1569-9285
DOI:10.1093/icvts/ivy188

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