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Molecular characterization of medulloblastomas with extensive nodularity (MBEN)

Medulloblastoma with extensive nodularity (MBEN) is a rare histological variant of medulloblastoma (MB). These tumors are usually occurring in the first 3 years of life and are associated with good prognosis. Molecular analyses of MBEN, mostly limited to single cases or small series, have shown that...

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Main Authors: Korshunov, Andrey (Author) , Sahm, Felix (Author) , Stichel, Damian (Author) , Schrimpf, Daniel (Author) , Lichter, Peter (Author) , Jones, David T. W. (Author) , Deimling, Andreas von (Author) , Pfister, Stefan (Author) , Kool, Marcel (Author)
Format: Article (Journal)
Language:English
Published: 22 March 2018
In: Acta neuropathologica
Year: 2018, Volume: 136, Issue: 2, Pages: 303-313
ISSN:1432-0533
DOI:10.1007/s00401-018-1840-0
Online Access:Resolving-System, Volltext: https://doi.org/10.1007/s00401-018-1840-0
Verlag: https://link.springer.com/article/10.1007%2Fs00401-018-1840-0
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Author Notes:Andrey Korshunov, Felix Sahm, Damian Stichel, Daniel Schrimpf, Marina Ryzhova, Olga Zheludkova, Andrey Golanov, Peter Lichter, David T. W. Jones, Andreas von Deimling, Stefan M. Pfister, Marcel Kool
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Summary:Medulloblastoma with extensive nodularity (MBEN) is a rare histological variant of medulloblastoma (MB). These tumors are usually occurring in the first 3 years of life and are associated with good prognosis. Molecular analyses of MBEN, mostly limited to single cases or small series, have shown that they always classify as sonic hedgehog (SHH)-driven MB. Here, we have analyzed 25 MBEN through genome-wide DNA methylation, copy-number profiling and targeted next-generation sequencing.
Item Description:Gesehen am 22.01.2020
Physical Description:Online Resource
ISSN:1432-0533
DOI:10.1007/s00401-018-1840-0

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