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The significance of batch and patch test method in establishing contact allergy to fragrance mix I: EDEN Fragrance Study Group

Background A fragrance mix consisting of eight separate fragrance ingredients (fragrance mix I [FM I]) is present in most baseline patch test series. Patch testing with the TRUE Test technique is considered to detect less contact allergy to FM I than testing with the Finn Chamber technique. Objectiv...

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Bibliographic Details
Main Authors: Bruze, Magnus (Author) , Mowitz, Martin (Author) , Ofenloch, Robert (Author) , Coenraads, Pieter-Jan (Author) , Diepgen, Thomas L. (Author) , Elsner, Peter (Author) , Gonçalo, Margarida (Author) , Naldi, Luigi (Author) , Svensson, Åke (Author)
Format: Article (Journal)
Language:English
Published: 27 February 2019
In: Contact dermatitis
Year: 2019, Volume: 81, Issue: 2, Pages: 104-109
ISSN:1600-0536
DOI:10.1111/cod.13253
Online Access:Verlag, Volltext: https://doi.org/10.1111/cod.13253
Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/cod.13253
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Author Notes:Magnus Bruze, Martin Mowitz, Robert Ofenloch, Pieter-Jan Coenraads, Thomas L. Diepgen, Peter Elsner, Margarida Gonçalo, Luigi Naldi, Åke Svensson
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Summary:Background A fragrance mix consisting of eight separate fragrance ingredients (fragrance mix I [FM I]) is present in most baseline patch test series. Patch testing with the TRUE Test technique is considered to detect less contact allergy to FM I than testing with the Finn Chamber technique. Objective To investigate the possible significance of batch and patch test method in establishing contact allergy to FM I. Methods Three thousand one hundred and nineteen individuals representing a sample of the general population were patch tested with two batches of FM I with two patch test techniques at six dermatology clinics in five European countries. The TRUE Test technique and the Finn Chamber technique with pet. preparations were used. McNemar's test was used for statistical calculations. Results The contact allergy prevalences varied between 0.7% and 2.6%. The patch tests with the mixes containing Evernia prunastri (oak moss) with a high content of chloratranol/atranol resulted in substantially more positive reactions than the corresponding tests with the mixes containing oak moss with a low content of chloratranol/atranol. The Finn Chamber technique detected significantly more contact allergic reactions than the TRUE Test technique (P < 0.001). Conclusion The Finn Chamber technique detects more contact allergy to FM I than the TRUE Test technique.
Item Description:Gesehen am 22.01.2020
Physical Description:Online Resource
ISSN:1600-0536
DOI:10.1111/cod.13253

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