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Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a lethal disease with insufficient treatment strategies. Here the authors show that reduction of the microRNA MIRLET7D and hyperactivation of EP300 contribute to impaired epigenetic silencing by the MiCEE complex in pulmonary fibroblasts of IPF patients, and de...

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Main Authors: Rubio Nava, Karla Maria (Author) , Singh, Indrabahadur (Author) , Cordero, Julio (Author) , Dobreva, Gergana (Author) , Heikenwälder, Mathias (Author)
Format: Article (Journal)
Language:English
Published: 20 May 2019
In: Nature Communications
Year: 2019, Volume: 10
ISSN:2041-1723
DOI:10.1038/s41467-019-10066-7
Online Access:Verlag, Volltext: https://doi.org/10.1038/s41467-019-10066-7
Verlag: https://www.nature.com/articles/s41467-019-10066-7
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Author Notes:Karla Rubio, Indrabahadur Singh, Stephanie Dobersch, Pouya Sarvari, Stefan Günther, Julio Cordero, Aditi Mehta, Lukasz Wujak, Hector Cabrera-Fuentes, Cho-Ming Chao, Peter Braubach, Saverio Bellusci, Werner Seeger, Andreas Günther, Klaus T. Preissner, Malgorzata Wygrecka, Rajkumar Savai, Dulce Papy-Garcia, Gergana Dobreva, Mathias Heikenwalder, Soni Savai-Pullamsetti, Thomas Braun, Guillermo Barreto
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Summary:Idiopathic pulmonary fibrosis (IPF) is a lethal disease with insufficient treatment strategies. Here the authors show that reduction of the microRNA MIRLET7D and hyperactivation of EP300 contribute to impaired epigenetic silencing by the MiCEE complex in pulmonary fibroblasts of IPF patients, and demonstrate the benefit of inhibiting EP300 for the treatment of IPF.
Item Description:Gesehen am 27.01.2020
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-019-10066-7

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