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Karyopherin α2-dependent import of E2F1 and TFDP1 maintains protumorigenic stathmin expression in liver cancer

Members of the karyopherin superfamily serve as nuclear transport receptors/adaptor proteins and provide exchange of macromolecules between the nucleo- and cytoplasm. Emerging evidence suggests a subset of karyopherins to be dysregulated in hepatocarcinogenesis including karyopherin-α2 (KPNA2). Howe...

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Main Authors: Drucker, Elisabeth (Author) , Pusch, Stefan (Author) , Herpel, Esther (Author) , Goeppert, Benjamin (Author) , Rössler, Stephanie (Author) , Schirmacher, Peter (Author) , Breuhahn, Kai (Author)
Format: Article (Journal)
Language:English
Published: 29 November 2019
In: Cell communication and signaling
Year: 2019, Volume: 17, Issue: 1, Pages: 159
ISSN:1478-811X
DOI:10.1186/s12964-019-0456-x
Online Access:Verlag, Volltext: https://doi.org/10.1186/s12964-019-0456-x
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Author Notes:Elisabeth Drucker, Kerstin Holzer, Stefan Pusch, Juliane Winkler, Diego F. Calvisi, Eva Eiteneuer, Esther Herpel, Benjamin Goeppert, Stephanie Roessler, Alessandro Ori, Peter Schirmacher, Kai Breuhahn and Stephan Singer
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Summary:Members of the karyopherin superfamily serve as nuclear transport receptors/adaptor proteins and provide exchange of macromolecules between the nucleo- and cytoplasm. Emerging evidence suggests a subset of karyopherins to be dysregulated in hepatocarcinogenesis including karyopherin-α2 (KPNA2). However, the functional and regulatory role of KPNA2 in liver cancer remains incompletely understood.
Item Description:Gesehen am 27.01.2020
Physical Description:Online Resource
ISSN:1478-811X
DOI:10.1186/s12964-019-0456-x

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