FOXI1 immunohistochemistry differentiates benign renal oncocytoma from malignant chromophobe renal cell carcinoma
Background/Aim: Renal oncocytoma (RO) and chromophobe renal cell carcinoma (chRCC) are suggested to develop from α- and β-intercalated (IC) cells of the collecting duct expressing solute carrier family 4 member 1 (SLC4A1) and SLC26A4 under control of forkhead box 1 (FOXI1) transcription factor. The...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2019
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| In: |
Anticancer research
Year: 2019, Volume: 39, Issue: 6, Pages: 2785-2790 |
| ISSN: | 1791-7530 |
| DOI: | 10.21873/anticanres.13405 |
| Online Access: | Verlag, Volltext: https://doi.org/10.21873/anticanres.13405 Verlag, Volltext: http://ar.iiarjournals.org/content/39/6/2785 
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| Author Notes: | Agnes Molnar, Csenge Anna Horvath, Petra Czovek, Arpad Szanto and Gyula Kovacs |
| Summary: | Background/Aim: Renal oncocytoma (RO) and chromophobe renal cell carcinoma (chRCC) are suggested to develop from α- and β-intercalated (IC) cells of the collecting duct expressing solute carrier family 4 member 1 (SLC4A1) and SLC26A4 under control of forkhead box 1 (FOXI1) transcription factor. The aim of this study was to clarify the possible cellular origin and of RO and chRCC. Materials and Methods: Immunohistochemistry for aquaporin 2 (AQP2), FOXI1, SLC4A1 and SLC16A4 was applied to distinct types of renal cell tumors. Results: Nuclear FOXI1 staining occurred in 96% of 83 ROs, in 3% of 90 chRCCs and none of the other tumor types. The α-IC cell marker SLC4A1 was seen in 60% of RO and 11% of chRCC, whereas staining for the β-IC cell marker SLC26A4 was negative in all but one tumor. Conclusion: Although the origin of RO remains unclear, our findings suggest that FOXI1 immunohistochemistry is useful in differential diagnosis of RO from chRCC with overlapping histology. |
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| Item Description: | accepted May 23, 2019 Gesehen am 30.01.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1791-7530 |
| DOI: | 10.21873/anticanres.13405 |