NPM1 functions in epitranscriptomics
A new study identifies germline NPM1 mutations in people with dyskeratosis congenita. These NPM1 mutations inhibit ribosomal RNA 2´-O-methylation by decreasing the binding of the rRNA methyltransferase FBL to small nucleolar RNAs. Thus, NPM1 influences ribosomal functions via epitranscriptomic regul...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
30 September 2019
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| In: |
Nature genetics
Year: 2019, Volume: 51, Issue: 10, Pages: 1436-1437 |
| ISSN: | 1546-1718 |
| DOI: | 10.1038/s41588-019-0510-z |
| Online Access: | Verlag, Volltext: https://doi.org/10.1038/s41588-019-0510-z Verlag: https://www.nature.com/articles/s41588-019-0510-z 
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| Author Notes: | Fengbiao Zhou, Carsten Müller-Tidow |
| Summary: | A new study identifies germline NPM1 mutations in people with dyskeratosis congenita. These NPM1 mutations inhibit ribosomal RNA 2´-O-methylation by decreasing the binding of the rRNA methyltransferase FBL to small nucleolar RNAs. Thus, NPM1 influences ribosomal functions via epitranscriptomic regulation. |
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| Item Description: | Gesehen am 29.01.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1546-1718 |
| DOI: | 10.1038/s41588-019-0510-z |