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Ist eine Operation der Brust bei Komplettremission nach neoadjuvanter Chemotherapie des Mammakarzinoms notwendig?

<p>The likelihood of pathological complete remission (pCR) of breast cancer following neoadjuvant chemotherapy (NACT) is increasing; most of all in the triple negative and HER2 positive tumour subgroups. The question thus arises whether or not breast surgery is necessary when there is complete...

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Main Authors: Richter, Hannah (Author) , Hennigs, André (Author) , Schäfgen, Benedikt (Author) , Sohn, Christof (Author) , Golatta, Michael (Author) , Heil, Jörg (Author)
Format: Article (Journal)
Language:German
Published: 22 Januar 2018
In: Geburtshilfe und Frauenheilkunde
Year: 2018, Volume: 78, Issue: 01, Pages: 48-53
ISSN:1438-8804
DOI:10.1055/s-0043-124082
Online Access:Verlag, Volltext: https://doi.org/10.1055/s-0043-124082
Verlag: http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-124082
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Author Notes:Hannah Richter, André Hennigs, Benedikt Schaefgen, Markus Hahn, Jens Uwe Blohmer, Sherko Kümmel, Thorsten Kühn, Marc Thill, Kay Friedrichs, Christof Sohn, Michael Golatta, Jörg Heil
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Summary:<p>The likelihood of pathological complete remission (pCR) of breast cancer following neoadjuvant chemotherapy (NACT) is increasing; most of all in the triple negative and HER2 positive tumour subgroups. The question thus arises whether or not breast surgery is necessary when there is complete remission after NACT, and whether it provides any improvement of the oncological treatment result when tumour is no longer detectable. Avoiding surgery and possibly even radiotherapy would only be conceivable on the basis of a reliable diagnosis of pCR without operating. Current imaging does not achieve the necessary sensitivity and specificity to assure the diagnosis of pathological complete remission. Further studies are therefore required to determine which methods are best able to evaluate tumour response to NACT. Studies on image-guided, minimally invasive biopsies after NACT have delivered first promising results towards diagnosing pCR before surgery and could provide the basis for further studies on the possibility of avoiding surgery in this specific patient collective.</p>
Item Description:Supplementary material - deutschsprachige Zusatzinformation
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Physical Description:Online Resource
ISSN:1438-8804
DOI:10.1055/s-0043-124082

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