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Molecular characteristics and therapeutic vulnerabilities across paediatric solid tumours

Paediatric solid tumours are known to be divergent from adult malignancies. This Review describes the molecular landscape of paediatric solid tumours, the therapeutic vulnerabilities that can be targeted and the preclinical models available to test the efficacy of investigational drugs with a view t...

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Main Authors: Jones, David T. W. (Author) , Banito, Ana (Author) , Grünewald, Thomas G. P. (Author) , Haber, Michelle (Author) , Jäger, Natalie (Author) , Kool, Marcel (Author) , Milde, Till (Author) , Molenaar, Jan J. (Author) , Nabbi, Arash (Author) , Pugh, Trevor (Author) , Schleiermacher, Gudrun (Author) , Smith, Malcolm A. (Author) , Westermann, Frank (Author) , Pfister, Stefan (Author)
Format: Article (Journal)
Language:English
Published: 12 July 2019
In: Nature reviews. Cancer
Year: 2019, Volume: 19, Issue: 8, Pages: 420-438
ISSN:1474-1768
DOI:10.1038/s41568-019-0169-x
Online Access:Verlag, Volltext: https://doi.org/10.1038/s41568-019-0169-x
Verlag, Volltext: https://www.nature.com/articles/s41568-019-0169-x
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Author Notes:David T.W. Jones, Ana Banito, Thomas G.P. Grünewald, Michelle Haber, Natalie Jäger, Marcel Kool, Till Milde, Jan J. Molenaar, Arash Nabbi, Trevor J. Pugh, Gudrun Schleiermacher, Malcolm A. Smith, Frank Westermann and Stefan M. Pfister
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Summary:Paediatric solid tumours are known to be divergent from adult malignancies. This Review describes the molecular landscape of paediatric solid tumours, the therapeutic vulnerabilities that can be targeted and the preclinical models available to test the efficacy of investigational drugs with a view to accelerating translational progress.
Item Description:Gesehen am 06.02.2020
Physical Description:Online Resource
ISSN:1474-1768
DOI:10.1038/s41568-019-0169-x

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