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Lipid-coated mesoporous silica microparticles for the controlled delivery of β-galactosidase into intestines

β-Galactosidase has been drawing increasing attention for the treatment of lactose intolerance, but its delivery has been impeded by degradation under gastric conditions. We have demonstrated that the coating of mesoporous silica microparticles (diameter ≈ 9 µm, pore size ≈ 25 nm) with dioleoylphosp...

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Bibliographic Details
Main Authors: Pavel, Ileana-Alexandra (Author) , Amadei, Federico (Author) , Kaufmann, Stefan (Author) , Tanaka, Motomu (Author)
Format: Article (Journal)
Language:English
Published: [2018]
In: Journal of materials chemistry. B, Materials for biology and medicine
Year: 2018, Volume: 6, Issue: 35, Pages: 5633-5639
ISSN:2050-7518
DOI:10.1039/C8TB01114A
Online Access:Verlag, Volltext: https://doi.org/10.1039/C8TB01114A
Verlag, Volltext: https://pubs.rsc.org/en/content/articlelanding/2018/tb/c8tb01114a
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Author Notes:Ileana-Alexandra Pavel, Maxime Girardon, Sarah El Hajj, Stéphane Parant, Federico Amadei, Stefan Kaufmann, Motomu Tanaka, Vanessa Fierro, Alain Celzard, Nadia Canilho and Andreea Pasc
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Summary:β-Galactosidase has been drawing increasing attention for the treatment of lactose intolerance, but its delivery has been impeded by degradation under gastric conditions. We have demonstrated that the coating of mesoporous silica microparticles (diameter ≈ 9 µm, pore size ≈ 25 nm) with dioleoylphosphatidylcholine membranes significantly improved the loading capability and protected the enzymes from the loss of function under simulated gastric conditions. Once the particles are transferred to simulated intestinal conditions, the digestion of phosphatidylcholine with pancreatin led to the release of functional β-galactosidase. The coating of mesoporous silica nanoparticles with a single phospholipid bilayer opens up a large potential towards the controlled release of orally administrated drugs or enzymes to the intestines.
Item Description:Gesehen am 10.02.2020
Physical Description:Online Resource
ISSN:2050-7518
DOI:10.1039/C8TB01114A

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