Imaging features of multiple myeloma extramedullary lesions in the liver with 18F-FDG PET/CT, contrast-enhanced CT and MRI
Ηepatic involvement in multiple myeloma is not common; nevertheless, it is associated with poorer outcome. Heterogeneous features have been described in few published reports so far. We present the imaging findings of PET/CT in comparison to those of MRI for two multiple myeloma (MM) patients, one w...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
7 November 2019
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| In: |
Diagnostics
Year: 2019, Volume: 9, Issue: 4 |
| ISSN: | 2075-4418 |
| DOI: | 10.3390/diagnostics9040179 |
| Online Access: | Verlag, Volltext: https://doi.org/10.3390/diagnostics9040179 Verlag: https://www.mdpi.com/2075-4418/9/4/179 
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| Author Notes: | Dimitris Papamichail, Robert Hog, Hartmut Goldschmidt and Antonia Dimitrakopoulou-Strauss |
| Summary: | Ηepatic involvement in multiple myeloma is not common; nevertheless, it is associated with poorer outcome. Heterogeneous features have been described in few published reports so far. We present the imaging findings of PET/CT in comparison to those of MRI for two multiple myeloma (MM) patients, one with a liver lesion suspicious for myeloma metastasis on PET and one with multiple liver lesions suspicious for myeloma metastases on MRΙ. The subsequent ultrasound-guided needle biopsies confirmed the extramedullary spread of the disease in both patients. The first case exhibited a match in both functional imaging modalities (PET and MRI) but a mismatch of intense metabolic activity on 18F-fluorodeoxyglucose (18F-FDG) PET/CT and iso-attenuating liver parenchyma on contrast-enhanced CT. The second case showed a mismatch of signal elevation persistence on diffusion-weighted imaging (DWI) and physiologic 18F-FDG distribution in the liver parenchyma. These cases present different imaging features in MM lesions of the liver using PET/CT and MRI, reflecting the high disease heterogeneity in patients with MM and demonstrating that the use of both PET/CT and MRI may offer complementary information. |
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| Item Description: | Gesehen am 17.02.2020 |
| Physical Description: | Online Resource |
| ISSN: | 2075-4418 |
| DOI: | 10.3390/diagnostics9040179 |