Response to agomelatine treatment is independent of smoking status and dosage: results from the AGOPSYCH study
<p> <b>Introduction</b> Cigarette smoking influences response to antidepressant treatment. It accelerates the metabolism of several cytochrome P450 (CYP) subtypes, including CYP1A2, and therefore bears the risk of pharmacokinetic interactions with psychotropic drugs using that path...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
07.Mai 2018
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| In: |
Pharmacopsychiatry
Year: 2019, Volume: 52, Issue: 03, Pages: 142-146 |
| ISSN: | 1439-0795 |
| DOI: | 10.1055/a-0606-5240 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1055/a-0606-5240 Verlag: http://www.thieme-connect.de/DOI/DOI?10.1055/a-0606-5240 
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| Author Notes: | Susanne Englisch, Hanna Sophie Jung, Antje Lewien, Anna Becker, Ulrike Nowak, Hanna Braun, Sarah Eisenacher, Jascha Thiem, Andreas Meyer-Lindenberg, Mathias Zink |
| Summary: | <p> <b>Introduction</b> Cigarette smoking influences response to antidepressant treatment. It accelerates the metabolism of several cytochrome P450 (CYP) subtypes, including CYP1A2, and therefore bears the risk of pharmacokinetic interactions with psychotropic drugs using that pathway. Agomelatine is a substrate of CYP1A2; the association between nicotine use and agomelatine dosage, however, has never been studied before.</p> <p> <b>Methods</b> Smoking habits were correlated with agomelatine doses and treatment outcomes in a sample of 27 patients with lifetime diagnoses within the schizophrenia spectrum who received agomelatine treatment in addition to their stable antipsychotic treatment regimen because of depressive symptoms.</p> <p> <b>Results</b> No interactions were found between smoking status and agomelatine dosage, and treatment outcomes did not differ between smokers and nonsmokers.</p> <p> <b>Discussion</b> Agomelatine efficacy appears to be independent of dosage and smoking status, pointing toward mechanisms beyond mere dose-response relationships. Further research will be necessary to validate these findings.</p> |
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| Item Description: | Gesehen am 18.02.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1439-0795 |
| DOI: | 10.1055/a-0606-5240 |