Distinct migratory pattern of naive and effector T cells through the blood-CSF barrier following Echovirus 30 infection

Echovirus 30 (E-30) is one of the most frequently isolated pathogens in aseptic meningitis worldwide. To gain access to the central nervous system (CNS), E-30 and immune cells have to cross one of the two main barriers of the CNS, the epithelial blood-cerebrospinal fluid barrier (BCSFB) or the endot...

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Hauptverfasser: Wiatr, Marie (VerfasserIn) , Stump-Guthier, Carolin (VerfasserIn) , Uhlig, Stefanie (VerfasserIn) , Weiß, Christel (VerfasserIn) , Schwerk, Christian (VerfasserIn) , Schroten, Horst (VerfasserIn) , Tenenbaum, Tobias (VerfasserIn) , Rudolph, Henriette (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2019
In: Journal of neuroinflammation
Year: 2019, Jahrgang: 16
ISSN:1742-2094
DOI:10.1186/s12974-019-1626-x
Online-Zugang:Verlag, Volltext: https://doi.org/10.1186/s12974-019-1626-x
Volltext
Verfasserangaben:Marie Wiatr, Carolin Stump-Guthier, Daniela Latorre, Stefanie Uhlig, Christel Weiss, Jorma Ilonen, Britta Engelhardt, Hiroshi Ishikawa, Christian Schwerk, Horst Schroten, Tobias Tenenbaum and Henriette Rudolph
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Zusammenfassung:Echovirus 30 (E-30) is one of the most frequently isolated pathogens in aseptic meningitis worldwide. To gain access to the central nervous system (CNS), E-30 and immune cells have to cross one of the two main barriers of the CNS, the epithelial blood-cerebrospinal fluid barrier (BCSFB) or the endothelial blood-brain barrier (BBB). In an in vitro model of the BCSFB, it has been shown that E-30 can infect human immortalized brain choroid plexus papilloma (HIBCPP) cells.
Beschreibung:Gesehen am 19.02.2020
Beschreibung:Online Resource
ISSN:1742-2094
DOI:10.1186/s12974-019-1626-x