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Distinct migratory pattern of naive and effector T cells through the blood-CSF barrier following Echovirus 30 infection

Echovirus 30 (E-30) is one of the most frequently isolated pathogens in aseptic meningitis worldwide. To gain access to the central nervous system (CNS), E-30 and immune cells have to cross one of the two main barriers of the CNS, the epithelial blood-cerebrospinal fluid barrier (BCSFB) or the endot...

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Main Authors: Wiatr, Marie (Author) , Stump-Guthier, Carolin (Author) , Uhlig, Stefanie (Author) , Weiß, Christel (Author) , Schwerk, Christian (Author) , Schroten, Horst (Author) , Tenenbaum, Tobias (Author) , Rudolph, Henriette (Author)
Format: Article (Journal)
Language:English
Published: 2019
In: Journal of neuroinflammation
Year: 2019, Volume: 16
ISSN:1742-2094
DOI:10.1186/s12974-019-1626-x
Online Access:Verlag, Volltext: https://doi.org/10.1186/s12974-019-1626-x
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Author Notes:Marie Wiatr, Carolin Stump-Guthier, Daniela Latorre, Stefanie Uhlig, Christel Weiss, Jorma Ilonen, Britta Engelhardt, Hiroshi Ishikawa, Christian Schwerk, Horst Schroten, Tobias Tenenbaum and Henriette Rudolph
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Summary:Echovirus 30 (E-30) is one of the most frequently isolated pathogens in aseptic meningitis worldwide. To gain access to the central nervous system (CNS), E-30 and immune cells have to cross one of the two main barriers of the CNS, the epithelial blood-cerebrospinal fluid barrier (BCSFB) or the endothelial blood-brain barrier (BBB). In an in vitro model of the BCSFB, it has been shown that E-30 can infect human immortalized brain choroid plexus papilloma (HIBCPP) cells.
Item Description:Gesehen am 19.02.2020
Physical Description:Online Resource
ISSN:1742-2094
DOI:10.1186/s12974-019-1626-x

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