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Plasma sRAGE is independently associated with increased mortality in ARDS: a meta-analysis of individual patient data

The soluble receptor for advanced glycation end-products (sRAGE) is a marker of lung epithelial injury and alveolar fluid clearance (AFC), with promising values for assessing prognosis and lung injury severity in acute respiratory distress syndrome (ARDS). Because AFC is impaired in most patients wi...

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Bibliographic Details
Main Authors: Jabaudon, Matthieu (Author) , Lichtenstern, Christoph (Author) , Uhle, Florian (Author)
Format: Article (Journal)
Language:English
Published: 26 July 2018
In: Intensive care medicine
Year: 2018, Volume: 44, Issue: 9, Pages: 1388-1399
ISSN:1432-1238
DOI:10.1007/s00134-018-5327-1
Online Access:Verlag, Volltext: https://doi.org/10.1007/s00134-018-5327-1
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Author Notes:Matthieu Jabaudon, Raiko Blondonnet, Bruno Pereira, Rodrigo Cartin-Ceba, Christoph Lichtenstern, Tommaso Mauri, Rogier M. Determann, Tomas Drabek, Rolf D. Hubmayr, Ognjen Gajic, Florian Uhle, Andrea Coppadoro, Antonio Pesenti, Marcus J. Schultz, Marco V. Ranieri, Helena Brodska, Ségolène Mrozek, Vincent Sapin, Michael A. Matthay, Jean-Michel Constantin, Carolyn S. Calfee
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Summary:The soluble receptor for advanced glycation end-products (sRAGE) is a marker of lung epithelial injury and alveolar fluid clearance (AFC), with promising values for assessing prognosis and lung injury severity in acute respiratory distress syndrome (ARDS). Because AFC is impaired in most patients with ARDS and is associated with higher mortality, we hypothesized that baseline plasma sRAGE would predict mortality, independently of two key mediators of ventilator-induced lung injury.
Item Description:Gesehen am 20.02.2020
Physical Description:Online Resource
ISSN:1432-1238
DOI:10.1007/s00134-018-5327-1

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