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In vivo laser confocal microscopy using the HRT-Rostock cornea module: Diversity and Diagnostic Implications in Patients with Uveitis

Purpose: Keratic precipitates (KP) are a common feature of uveitis. We prospectively examined KP with the Heidelberg Retinal Tomograph II confocal laser scanning microscope and Rostock Corneal Module (HRT-RCM) to explore their diagnostic implications.Methods: Prospective, observational, multicenter...

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Bibliographic Details
Main Authors: Lim, Lyndell L. (Author) , Becker, Matthias D. (Author) , Mackensen, Friederike (Author)
Format: Article (Journal)
Language:English
Published: [2018]
In: Ocular immunology and inflammation
Year: 2017, Volume: 26, Issue: 6, Pages: 900-909
ISSN:1744-5078
DOI:10.1080/09273948.2017.1298818
Online Access:Verlag, Volltext: https://doi.org/10.1080/09273948.2017.1298818
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Author Notes:Lyndell L. Lim, Jing Xie, Chyn C. Chua, Tiffany Wong, Lani T. Hoang, Matthias D. Becker, Eric B. Suhler, James T. Rosenbaum, Friederike Mackensen
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Summary:Purpose: Keratic precipitates (KP) are a common feature of uveitis. We prospectively examined KP with the Heidelberg Retinal Tomograph II confocal laser scanning microscope and Rostock Corneal Module (HRT-RCM) to explore their diagnostic implications.Methods: Prospective, observational, multicenter study. HRT-RCM images were classified by two masked observers.Results: 120 scans on 120 eyes from 110 subjects were included. The majority (N = 93) had non-infectious uveitis. Sixty eyes had active disease at scanning. Eight KP morphologies were defined. Agreement between the two masked graders was high (Kappa value across all categories = 0.81). Cluster and nodular KP were associated with active infectious uveitis (p < 0.01): patients with cluster KP (odds ratio [OR] = 3.03, 95% confidence interval [CI]: 1.43, 6.45) and nodular KP (OR = 3.89, 95% CI: 1.42, 10.65) were more likely to have infectious uveitis than those without.Conclusions: Laser confocal microscopy of KP may have a role in determining between infectious and non-infectious uveitis.
Item Description:Published online: 31 May 2017
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Physical Description:Online Resource
ISSN:1744-5078
DOI:10.1080/09273948.2017.1298818

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