Threshold isocontouring on high b-value diffusion-weighted images in magnetic resonance mammography
Objectives Motivated by the similar appearance of malignant breast lesions in high b-value diffusion-weighted imaging (DWI) and positron emission tomography, the purpose of this work was to evaluate the applicability of a threshold isocontouring approach commonly used in positron emission tomography...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
May/June 2019
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| In: |
Journal of computer assisted tomography
Year: 2019, Volume: 43, Issue: 3, Pages: 434-442 |
| ISSN: | 1532-3145 |
| DOI: | 10.1097/RCT.0000000000000868 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1097/RCT.0000000000000868 Verlag, Volltext: https://journals.lww.com/jcat/Abstract/2019/05000/Threshold_Isocontouring_on_High_b_Value.13.aspx 
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| Author Notes: | Fangrong Zong, Sebastian Bickelhaupt, Tristan Anselm Kuder, Wolfgang Lederer, Heidi Daniel, Anne Stieber, Heinz-Peter Schlemmer, Petrik Galvosas, Frederik Bernd Laun |
| Summary: | Objectives Motivated by the similar appearance of malignant breast lesions in high b-value diffusion-weighted imaging (DWI) and positron emission tomography, the purpose of this work was to evaluate the applicability of a threshold isocontouring approach commonly used in positron emission tomography to analyze DWI data acquired from female human breasts with minimal interobserver variability. - Methods Twenty-three female participants (59.4 ± 10.0 years) with 23 lesions initially classified as suggestive of cancers in x-ray mammography screening were subsequently imaged on a 1.5-T magnetic resonance imaging scanner. Diffusion-weighted imaging was performed prior to biopsy with b values of 0, 100, 750, and 1500 s/mm2. Isocontouring with different threshold levels was performed on the highest b-value image to determine the voxels used for subsequent evaluation of diffusion metrics. The coefficient of variation was computed by specifying 4 different regions of interest drawn around the lesion. Additionally, a receiver operating statistical analysis was performed. - Results Using a relative threshold level greater than or equal to 0.85 almost completely suppresses the intra-individual and inter-individual variability. Among 4 studied diffusion metrics, the diffusion coefficients from the intravoxel incoherent motion model returned the highest area under curve value of 0.9. The optimal cut-off diffusivity was found to be 0.85 μm2/ms with a sensitivity of 87.5% and specificity of 90.9%. - Conclusion Threshold isocontouring on high b-value maps is a viable approach to reliably evaluate DWI data of suspicious focal lesions in magnetic resonance mammography. |
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| Item Description: | Gesehen am 24.02.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1532-3145 |
| DOI: | 10.1097/RCT.0000000000000868 |