Borohydride intermediates pave the way for magnesium-catalysed enantioselective ketone reduction
A magnesium precatalyst for the highly enantioselective hydro-boration of CO bonds is reported. The mechanistic basis of the unprecedented selectivity of this transformation has been investi-gated experimentally by isolation of catalytic intermediates and theoretically by DFT calculations. The facil...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2020
|
| In: |
Chemical communications
Year: 2019, Jahrgang: 56, Heft: 8, Pages: 1203-1206 |
| ISSN: | 1364-548X |
| DOI: | 10.1039/C9CC09111D |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1039/C9CC09111D Verlag: https://pubs.rsc.org/en/content/articlelanding/2020/cc/c9cc09111d 
|
| Verfasserangaben: | Vladislav Vasilenko, Clemens K. Blasius, Hubert Wadepohl and Lutz H. Gade |
| Zusammenfassung: | A magnesium precatalyst for the highly enantioselective hydro-boration of CO bonds is reported. The mechanistic basis of the unprecedented selectivity of this transformation has been investi-gated experimentally by isolation of catalytic intermediates and theoretically by DFT calculations. The facile formation of a magnesium borohydride species is critical in overcoming competing pathways in the selectivity-determining insertion step. |
|---|---|
| Beschreibung: | First published 20 December 2019 Gesehen am 24.02.2020 |
| Beschreibung: | Online Resource |
| ISSN: | 1364-548X |
| DOI: | 10.1039/C9CC09111D |