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Making translation work: harmonizing cross-species methodology in the behavioural neuroscience of Pavlovian fear conditioning

Translational neuroscience bridges insights from specific mechanisms in rodents to complex functions in humans and is key to advance our general understanding of central nervous function. A prime example of translational research is the study of cross-species mechanisms that underlie responding to l...

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Main Authors: Haaker, Jan Gerrit (Author) , Maren, Stephen (Author) , Andreatta, Marta (Author) , Merz, Christian J. (Author) , Richter, Jan (Author) , Richter, S. Helene (Author) , Meir Drexler, Shira (Author) , Lange, Maren D. (Author) , Jüngling, Kay (Author) , Nees, Frauke (Author) , Seidenbecher, Thomas (Author) , Fullana, Miquel A. (Author) , Wotjak, Carsten T. (Author) , Lonsdorf, Tina B. (Author)
Format: Article (Journal)
Language:English
Published: 12 September 2019
In: Neuroscience & biobehavioral reviews
Year: 2019, Volume: 107, Pages: 329-345
ISSN:1873-7528
DOI:10.1016/j.neubiorev.2019.09.020
Online Access:Verlag, Volltext: https://doi.org/10.1016/j.neubiorev.2019.09.020
Verlag: http://www.sciencedirect.com/science/article/pii/S014976341930288X
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Author Notes:Jan Haaker, Stephen Maren, Marta Andreatta, Christian J. Merz, Jan Richter, S. Helene Richter, Shira Meir Drexler, Maren D. Lange, Kay Jüngling, Frauke Nees, Thomas Seidenbecher, Miquel A. Fullana, Carsten T. Wotjak, Tina B. Lonsdorf
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Summary:Translational neuroscience bridges insights from specific mechanisms in rodents to complex functions in humans and is key to advance our general understanding of central nervous function. A prime example of translational research is the study of cross-species mechanisms that underlie responding to learned threats, by employing Pavlovian fear conditioning protocols in rodents and humans. Hitherto, evidence for (and critique of) these cross-species comparisons in fear conditioning research was based on theoretical viewpoints. Here, we provide a perspective to substantiate these theoretical concepts with empirical considerations of cross-species methodology. This meta-research perspective is expected to foster cross-species comparability and reproducibility to ultimately facilitate successful transfer of results from basic science into clinical applications.
Item Description:Gesehen am 25.02.2020
Physical Description:Online Resource
ISSN:1873-7528
DOI:10.1016/j.neubiorev.2019.09.020

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