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Iron accumulation in tumor-associated macrophages marks an improved overall survival in patients with lung adenocarcinoma

Iron-loaded tumor-associated macrophages (iTAMs) show a pro-inflammatory phenotype, hallmarked by anti-tumorigenic activity and an ability to attenuate tumor growth. Here we explored the relevance of these findings in lung cancer patients by investigating the impact of the iTAM content in the tumor...

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Main Authors: Thielmann, Carl Maximilian (Author) , Costa da Silva, Milene (Author) , Muley, Thomas (Author) , Meister, Michael (Author) , Herpel, Esther (Author) , Muckenthaler, Martina (Author)
Format: Article (Journal)
Language:English
Published: 05 August 2019
In: Scientific reports
Year: 2019, Volume: 9
ISSN:2045-2322
DOI:10.1038/s41598-019-47833-x
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41598-019-47833-x
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41598-019-47833-x
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Author Notes:Carl Maximilian Thielmann, Milene Costa da Silva, Thomas Muley, Michael Meister, Esther Herpel, & Martina U. Muckenthaler
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Summary:Iron-loaded tumor-associated macrophages (iTAMs) show a pro-inflammatory phenotype, hallmarked by anti-tumorigenic activity and an ability to attenuate tumor growth. Here we explored the relevance of these findings in lung cancer patients by investigating the impact of the iTAM content in the tumor microenvironment (TME) on patient survival. We analyzed 102 human non-small cell lung cancer (NSCLC) paraffin-embedded archival tissue samples for iron levels and macrophage numbers. Interestingly, patients with lung adenocarcinoma accumulating iron in the TME show higher numbers of M1-like pro-inflammatory TAMs and a survival advantage compared to iron-negative patients. By contrast, in patients with lung squamous cell carcinoma iron in the TME does not affect survival, suggesting a unique influence of iron on different histological subtypes of non-small cell lung cancer (NSCLC). We conclude that in lung adenocarcinoma iron may serve as a prognostic marker for patient survival and as a potential therapeutic target for anti-cancer therapy.
Item Description:Gesehen am 28.02.2020
Physical Description:Online Resource
ISSN:2045-2322
DOI:10.1038/s41598-019-47833-x

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