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Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course

The “isomorphic subtype of diffuse astrocytoma” was identified histologically in 2004 as a supratentorial, highly differentiated glioma with low cellularity, low proliferation and focal diffuse brain infiltration. Patients typically had seizures since childhood and all were operated on as adults. To...

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Main Authors: Wefers, Annika K. (Author) , Stichel, Damian (Author) , Schrimpf, Daniel (Author) , Coras, Roland (Author) , Pages, Mélanie (Author) , Tauziède-Espariat, Arnault (Author) , Varlet, Pascale (Author) , Schwarz, Daniel (Author) , Söylemezoglu, Figen (Author) , Pohl, Ute (Author) , Pimentel, José (Author) , Meyer, Jochen (Author) , Hewer, Ekkehard (Author) , Japp, Anna (Author) , Joshi, Abhijit (Author) , Reuss, David (Author) , Reinhardt, Annekathrin (Author) , Sievers, Philipp (Author) , Casalini, Belén (Author) , Ebrahimi, Azadeh (Author) , Huang, Kristin (Author) , Kölsche, Christian (Author) , Pfister, Stefan (Author) , Sahm, Felix (Author) , Deimling, Andreas von (Author) , Jones, David T. W. (Author) , Blumcke, Ingmar (Author) , Capper, David (Author)
Format: Article (Journal)
Language:English
Published: 2020
In: Acta neuropathologica
Year: 2019, Volume: 139, Issue: 1, Pages: 193-209
ISSN:1432-0533
DOI:10.1007/s00401-019-02078-w
Online Access:Resolving-System, Volltext: https://doi.org/10.1007/s00401-019-02078-w
Verlag: https://link.springer.com/article/10.1007%2Fs00401-019-02078-w
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Author Notes:Annika K. Wefers, Damian Stichel, Daniel Schrimpf, Roland Coras, Mélanie Pages, Arnault Tauziède-Espariat, Pascale Varlet, Daniel Schwarz, Figen Söylemezoglu, Ute Pohl, José Pimentel, Jochen Meyer, Ekkehard Hewer, Anna Japp, Abhijit Joshi, David E. Reuss, Annekathrin Reinhardt, Philipp Sievers, M. Belén Casalini, Azadeh Ebrahimi, Kristin Huang, Christian Koelsche, Hu Liang Low, Olinda Rebelo, Dina Marnoto, Albert J. Becker, Ori Staszewski, Michel Mittelbronn, Martin Hasselblatt, Jens Schittenhelm, Edmund Cheesman, Ricardo Santos de Oliveira, Rosane Gomes P. Queiroz, Elvis Terci Valera, Volkmar H. Hans, Andrey Korshunov, Adriana Olar, Keith L. Ligon, Stefan M. Pfister, Zane Jaunmuktane, Sebastian Brandner, Ruth G. Tatevossian, David W. Ellison, Thomas S. Jacques, Mrinalini Honavar, Eleonora Aronica, Maria Thom, Felix Sahm, Andreas von Deimling, David T. W. Jones, Ingmar Blumcke, David Capper
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Summary:The “isomorphic subtype of diffuse astrocytoma” was identified histologically in 2004 as a supratentorial, highly differentiated glioma with low cellularity, low proliferation and focal diffuse brain infiltration. Patients typically had seizures since childhood and all were operated on as adults. To define the position of these lesions among brain tumours, we histologically, molecularly and clinically analysed 26 histologically prototypical isomorphic diffuse gliomas.
Item Description:Published online: 28 September 2019
Gesehen am 03.03.2020
Physical Description:Online Resource
ISSN:1432-0533
DOI:10.1007/s00401-019-02078-w

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