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Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals

Removal of the C. elegans germline substantially increases organismal lifespan. Here, Nakamura et al. show that the transcription factors MML-1 and MXL-2 coordinate this process in that they reduce TOR signalling and increase autophagy by regulating activity of HLH-30.

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Bibliographic Details
Main Authors: Nakamura, Shuhei (Author) , Karalay, Özlem (Author) , Jäger, Philipp S. (Author) , Horikawa, Makoto (Author) , Klein, Corinna (Author) , Nakamura, Kayo (Author) , Latza, Christian (Author) , Templer, Sven E. (Author) , Dieterich, Christoph (Author) , Antebi, Adam (Author)
Format: Article (Journal)
Language:English
Published: 22 March 2016
In: Nature Communications
Year: 2016, Volume: 7
ISSN:2041-1723
DOI:10.1038/ncomms10944
Online Access:Verlag, Volltext: https://doi.org/10.1038/ncomms10944
Verlag, Volltext: https://www.nature.com/articles/ncomms10944
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Author Notes:Shuhei Nakamura, Özlem Karalay, Philipp S. Jäger, Makoto Horikawa, Corinna Klein, Kayo Nakamura, Christian Latza, Sven E. Templer, Christoph Dieterich & Adam Antebi
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Summary:Removal of the C. elegans germline substantially increases organismal lifespan. Here, Nakamura et al. show that the transcription factors MML-1 and MXL-2 coordinate this process in that they reduce TOR signalling and increase autophagy by regulating activity of HLH-30.
Item Description:Gesehen am 03.03.2020
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/ncomms10944

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