The evolving landscape of brain metastasis
Metastasis, involving the spread of systemic cancer to the brain, results in neurologic disability and death. Current treatments are largely palliative in nature; improved therapeutic approaches represent an unmet clinical need. However, recent experimental and clinical advances challenge the bleak...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2018
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| In: |
Trends in cancer
Year: 2019, Volume: 4, Issue: 3, Pages: 176-196 |
| ISSN: | 2405-8025 |
| DOI: | 10.1016/j.trecan.2018.01.003 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1016/j.trecan.2018.01.003 Verlag, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602095/ 
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| Author Notes: | Manuel Valiente, Manmeet S. Ahluwalia, Adrienne Boire, Priscilla K. Brastianos, Sarah B. Goldberg, Eudocia Q. Lee, Emilie Le Rhun, Matthias Preusser, Frank Winkler, and Riccardo Soffietti |
| Summary: | Metastasis, involving the spread of systemic cancer to the brain, results in neurologic disability and death. Current treatments are largely palliative in nature; improved therapeutic approaches represent an unmet clinical need. However, recent experimental and clinical advances challenge the bleak longterm outcome of this disease. Encompassing key recent findings in epidemiology, genetics, microenvironment, leptomeningeal disease, neurocognition, targeted therapy, immunotherapy, and prophylaxis, we review preclinical and clinical studies to provide a comprehensive picture of contemporary research and the management of secondary brain tumors. |
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| Item Description: | Gesehen am 03.03.2020 Published online: 2019 July 01 |
| Physical Description: | Online Resource |
| ISSN: | 2405-8025 |
| DOI: | 10.1016/j.trecan.2018.01.003 |