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Mimicking age-associated Gadd45γ dysregulation results in memory impairments in young adult mice

Age-related memory loss is observed across multiple mammalian species and preferentially affects hippocampus-dependent memory. Memory impairments are characterized by accelerated decay of spatial memories. Nevertheless, the molecular mechanisms underlying these deficits are still largely unknown. He...

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Bibliographic Details
Main Authors: Brito, David V. C. (Author) , Kupke, Janina (Author) , Gülmez Karaca, Kübra (Author) , Zeuch, Benjamin (Author) , Oliveira, Ana (Author)
Format: Article (Journal)
Language:English
Published: February 5, 2020
In: The journal of neuroscience
Year: 2020, Volume: 40, Issue: 6, Pages: 1197-1210
ISSN:1529-2401
DOI:10.1523/JNEUROSCI.1621-19.2019
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1523/JNEUROSCI.1621-19.2019
Verlag, lizenzpflichtig, Volltext: https://www.jneurosci.org/content/40/6/1197
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Author Notes:David V.C. Brito, Janina Kupke, Kubra Gulmez Karaca, Benjamin Zeuch, and Ana M.M. Oliveira
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Summary:Age-related memory loss is observed across multiple mammalian species and preferentially affects hippocampus-dependent memory. Memory impairments are characterized by accelerated decay of spatial memories. Nevertheless, the molecular mechanisms underlying these deficits are still largely unknown. Here, we investigated the expression and function of the growth arrest DNA damage (Gadd45) family during aging and cognition, respectively.
Item Description:Gesehen am 06.03.2020
Physical Description:Online Resource
ISSN:1529-2401
DOI:10.1523/JNEUROSCI.1621-19.2019

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