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Cited4 is a sex-biased mediator of the antidiabetic glitazone response in adipocyte progenitors

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Most antidiabetic drugs treat disease symptoms rather than adipose tissue dysfunction as a key pathogenic cause in the metabolic syndrome and type 2 diabetes. Pharmacological targeting of adipose tissue through the nuclear receptor PPARg, as exemplified by glitazone treatments, mediates efficacious...

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Autori principali: Bayındır-Buchhalter, İrem (Autore) , Wolff, Gretchen (Autore) , Lerch, Sarah (Autore) , Sijmonsma, Tjeerd P. (Autore) , Schuster, Maximilian (Autore) , Gronych, Jan (Autore) , Billeter, Adrian (Autore) , Babaei, Rohollah (Autore) , Krunic, Damir (Autore) , Ruas, Jorge L. (Autore) , Müller, Beat P. (Autore) , Lichter, Peter (Autore) , Herzig, Stephan (Autore) , Vegiopoulos, Alexandros (Autore)
Natura: Article (Journal)
Lingua:inglese
Pubblicazione: 4 July 2018
In: EMBO molecular medicine
Year: 2018, Volume: 10, Fascicolo: 8, Pages: 1-18
ISSN:1757-4684
DOI:10.15252/emmm.201708613
Accesso online:Verlag, kostenfrei, Volltext: https://doi.org/10.15252/emmm.201708613
Verlag, kostenfrei, Volltext: https://www.embopress.org/doi/full/10.15252/emmm.201708613
Testo
Note sull'autore:Irem Bayindir-Buchhalter, Gretchen Wolff, Sarah Lerch, Tjeerd Sijmonsma, Maximilian Schuster, Jan Gronych, Adrian T Billeter, Rohollah Babaei, Damir Krunic, Lars Ketscher, Nadine Spielmann, Martin Hrabe de Angelis, Jorge L Ruas, Beat P Müller-Stich, Mathias Heikenwalder, Peter Lichter, Stephan Herzig & Alexandros Vegiopoulos
Descrizione
Riassunto:Most antidiabetic drugs treat disease symptoms rather than adipose tissue dysfunction as a key pathogenic cause in the metabolic syndrome and type 2 diabetes. Pharmacological targeting of adipose tissue through the nuclear receptor PPARg, as exemplified by glitazone treatments, mediates efficacious insulin sensitization. However, a better understanding of the context-specific PPARg responses is required for the development of novel approaches with reduced side effects. Here, we identified the transcriptional cofactor Cited4 as a target and mediator of rosiglitazone in human and murine adipocyte progenitor cells, where it promoted specific sets of the rosiglitazone-dependent transcriptional program. In mice, Cited4 was required for the proper induction of thermogenic expression by Rosi specifically in subcutaneous fat. This phenotype had high penetrance in females only and was not evident in beta-adrenergically stimulated browning. Intriguingly, this specific defect was associated with reduced capacity for systemic thermogenesis and compromised insulin sensitization upon therapeutic rosiglitazone treatment in female but not male mice. Our findings on Cited4 function reveal novel unexpected aspects of the pharmacological targeting of PPARg.
Descrizione del documento:Gesehen am 04.03.2025
Descrizione fisica:Online Resource
ISSN:1757-4684
DOI:10.15252/emmm.201708613

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